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dc.contributor.authorMarina, N
dc.contributor.authorAbdala, APL
dc.contributor.authorKorsak, A
dc.contributor.authorSimms, AE
dc.contributor.authorAllen, AM
dc.contributor.authorPaton, JFR
dc.contributor.authorGourine, AV
dc.date.available2014-05-22T03:04:41Z
dc.date.issued2011-09-01
dc.identifierpii: cvr128
dc.identifier.citationMarina, N., Abdala, A. P. L., Korsak, A., Simms, A. E., Allen, A. M., Paton, J. F. R. & Gourine, A. V. (2011). Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata. CARDIOVASCULAR RESEARCH, 91 (4), pp.703-710. https://doi.org/10.1093/cvr/cvr128.
dc.identifier.issn0008-6363
dc.identifier.urihttp://hdl.handle.net/11343/31321
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractAIMS: Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses. METHODS AND RESULTS: In anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ, C1 neurones were acutely silenced by application of the insect peptide allatostatin following cell-specific targeting with a lentiviral vector to express the inhibitory Drosophila allatostatin receptor. In anaesthetized rats with denervated peripheral chemoreceptors, acute inhibition of 50% of the C1 neuronal population resulted in ∼50% reduction in renal sympathetic nerve activity and a profound fall in arterial blood pressure (by ∼25 mmHg). However, under these conditions systemic hypercapnia still evoked vigorous sympathetic activation and the slopes of the CO(2)-evoked sympathoexcitatory and cardiovascular responses were not affected by inhibition of C1 neurones. Inhibition of C1 neurones in situ resulted in a reversible fall in perfusion pressure and the amplitude of respiratory-related bursts of thoracic sympathetic nerve activity. CONCLUSION: These data confirm a fundamental physiological role of medullary catecholaminergic C1 neurones in maintaining resting sympathetic vasomotor tone and arterial blood pressure. However, C1 neurones do not appear to mediate sympathoexcitation evoked by central actions of CO(2).
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.subjectAnimal Physiology - Systems; Autonomic Nervous System; Expanding Knowledge in the Biological Sciences; Expanding Knowledge in the Medical and Health Sciences; Cardiovascular System and Diseases; Nervous System and Disorders
dc.titleControl of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata
dc.typeJournal Article
dc.identifier.doi10.1093/cvr/cvr128
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPhysiology
melbourne.source.titleCARDIOVASCULAR RESEARCH
melbourne.source.volume91
melbourne.source.issue4
melbourne.source.pages703-710
dc.research.codefor060603
dc.research.codefor110901
dc.research.codeseo2008970106
dc.research.codeseo2008970111
dc.research.codeseo2008920103
dc.research.codeseo2008920111
dc.rights.licenseCC BY-NC
melbourne.publicationid168321
melbourne.elementsid337878
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156904
melbourne.contributor.authorAllen, Andrew
melbourne.contributor.authorSIMMS, ANNABEL
dc.identifier.eissn1755-3245
melbourne.conference.locationEngland
melbourne.accessrightsAccess this item via the Open Access location


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