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    Septic Acute Kidney Injury: The Glomerular Arterioles

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    20
    Author
    Bellomo, R; Wan, L; Langenberg, C; Ishikawa, K; May, CN
    Editor
    Kellum, JA; Ronco, C; Vincent, JL
    Date
    2011-01-01
    Source Title
    CONTROVERSIES IN ACUTE KIDNEY INJURY
    Publisher
    KARGER
    University of Melbourne Author/s
    Bellomo, Rinaldo; May, Clive
    Affiliation
    Surgery - Austin Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Bellomo, R., Wan, L., Langenberg, C., Ishikawa, K. & May, C. N. (2011). Septic Acute Kidney Injury: The Glomerular Arterioles. CONTROVERSIES IN ACUTE KIDNEY INJURY, 174, pp.98-107. https://doi.org/10.1159/000329246.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/31341
    DOI
    10.1159/000329246
    Description

    C1 - Journal Articles Refereed

    Abstract
    Acute kidney injury (AKI) is a serious condition that affects many intensive care unit (ICU) patients. The most common causes of AKI in the ICU are severe sepsis and septic shock. The mortality of AKI in septic critically ill patients remains high despite our increasing ability to support vital organs. This is partly due to our poor understanding of the pathogenesis of sepsis-induced renal dysfunction. However, new concepts are emerging to explain the pathogenesis of septic AKI, which challenge previously held dogma. Throughout the past half century, septic AKI has essentially been considered secondary to tubular injury, which, in turn, has been considered secondary to renal ischemia. This belief is curious because the hallmark of septic AKI and AKI in general is the loss of glomerular filtration rate (GFR). It would seem logical, therefore, to focus on the glomerulus in trying to understand why such loss of GFR occurs. Recent experimental observations suggest that, at least in the initial phases of septic AKI, profound changes occur which involve glomerular hemodynamics and lead to loss of GFR. These observations imply that changes in the vasoconstrictor tone of both the afferent and efferent arterioles are an important component of the pathogenesis of septic AKI.
    Keywords
    Clinical Sciences not elsewhere classified; Clinical Health (Organs; Diseases and Abnormal Conditions) not elsewhere classified

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