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dc.contributor.authorBellomo, R
dc.contributor.authorWan, L
dc.contributor.authorLangenberg, C
dc.contributor.authorIshikawa, K
dc.contributor.authorMay, CN
dc.contributor.editorKellum, JA
dc.contributor.editorRonco, C
dc.contributor.editorVincent, JL
dc.identifierpii: 000329246
dc.identifier.citationBellomo, R., Wan, L., Langenberg, C., Ishikawa, K. & May, C. N. (2011). Septic Acute Kidney Injury: The Glomerular Arterioles. CONTROVERSIES IN ACUTE KIDNEY INJURY, 174, pp.98-107.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractAcute kidney injury (AKI) is a serious condition that affects many intensive care unit (ICU) patients. The most common causes of AKI in the ICU are severe sepsis and septic shock. The mortality of AKI in septic critically ill patients remains high despite our increasing ability to support vital organs. This is partly due to our poor understanding of the pathogenesis of sepsis-induced renal dysfunction. However, new concepts are emerging to explain the pathogenesis of septic AKI, which challenge previously held dogma. Throughout the past half century, septic AKI has essentially been considered secondary to tubular injury, which, in turn, has been considered secondary to renal ischemia. This belief is curious because the hallmark of septic AKI and AKI in general is the loss of glomerular filtration rate (GFR). It would seem logical, therefore, to focus on the glomerulus in trying to understand why such loss of GFR occurs. Recent experimental observations suggest that, at least in the initial phases of septic AKI, profound changes occur which involve glomerular hemodynamics and lead to loss of GFR. These observations imply that changes in the vasoconstrictor tone of both the afferent and efferent arterioles are an important component of the pathogenesis of septic AKI.
dc.subjectClinical Sciences not elsewhere classified; Clinical Health (Organs
dc.subjectDiseases and Abnormal Conditions) not elsewhere classified
dc.titleSeptic Acute Kidney Injury: The Glomerular Arterioles
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentSurgery - Austin Health
melbourne.source.titleContributions to Nephrology
melbourne.contributor.authorBellomo, Rinaldo
melbourne.contributor.authorMay, Clive
melbourne.fieldofresearch320299 Clinical sciences not elsewhere classified
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

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