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    Neurotrophic factors and neural prostheses: Potential clinical applications based upon findings in the auditory system

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    72
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    Author
    Pettingill, LN; Richardson, RT; Wise, AK; O'Leary, SJ; Shepherd, RK
    Date
    2007-06-01
    Source Title
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
    Publisher
    IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
    University of Melbourne Author/s
    Richardson, Rachael; Wise, Andrew; O'Leary, Stephen; Shepherd, Robert; Gillespie, Lisa
    Affiliation
    Audiology and Speech Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Pettingill, L. N., Richardson, R. T., Wise, A. K., O'Leary, S. J. & Shepherd, R. K. (2007). Neurotrophic factors and neural prostheses: Potential clinical applications based upon findings in the auditory system. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 54 (6), pp.1138-1148. https://doi.org/10.1109/TBME.2007.895375.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/31633
    DOI
    10.1109/TBME.2007.895375
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886005
    Abstract
    Spiral ganglion neurons (SGNs) are the target cells of the cochlear implant, a neural prosthesis designed to provide important auditory cues to severely or profoundly deaf patients. The ongoing degeneration of SGNs that occurs following a sensorineural hearing loss is, therefore, considered a limiting factor in cochlear implant efficacy. We review neurobiological techniques aimed at preventing SGN degeneration using exogenous delivery of neurotrophic factors. Application of these proteins prevents SGN degeneration and can enhance neurite outgrowth. Furthermore, chronic electrical stimulation of SGNs increases neurotrophic factor-induced survival and is correlated with functional benefits. The application of neurotrophic factors has the potential to enhance the benefits that patients can derive from cochlear implants; moreover, these techniques may be relevant for use with neural prostheses in other neurological conditions.
    Keywords
    Artificial Intelligence and Image Processing

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