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    Myoblast Cell Interaction with Polydopamine Coated Liposomes

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    Author
    van der Westen, R; Hosta-Rigau, L; Sutherland, DS; Goldie, KN; Albericio, F; Postma, A; Stadler, B
    Date
    2012-12-01
    Source Title
    BIOINTERPHASES
    Publisher
    AMER INST PHYSICS
    University of Melbourne Author/s
    POSTMA, ALMAR
    Affiliation
    Chemical And Biomolecular Engineering
    Metadata
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    Document Type
    Journal Article
    Citations
    van der Westen, R., Hosta-Rigau, L., Sutherland, D. S., Goldie, K. N., Albericio, F., Postma, A. & Stadler, B. (2012). Myoblast Cell Interaction with Polydopamine Coated Liposomes. BIOINTERPHASES, 7 (1-4), https://doi.org/10.1007/s13758-011-0008-4.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/32631
    DOI
    10.1007/s13758-011-0008-4
    Description

    C1 - Journal Articles Refereed

    Abstract
    Liposomes are widely used, from biosensing to drug delivery. Their coating with polymers for stability and functionalization purposes further broadens their set of relevant properties. Poly(dopamine) (PDA), a eumelanin-like material deposited via the "self"-oxidative polymerization of dopamine at mildly basic pH, has attracted considerable interest in the past few years due to its simplicity, flexibility yet fascinating properties. Herein, we characterize the coating of different types of liposomes with PDA depending on the presence of oleoyldopamine in the lipid bilayer and the dopamine hydrochloride concentration. Further, the interaction of these coated liposomes in comparison to their uncoated counterparts with myoblast cells is assessed. Their uptake/association efficiency with these cells is determined. Further, their dose-dependent cytotoxicity with and without entrapped hydrophobic cargo (thiocoraline) is characterized. Taken together, the reported results demonstrate the potential of PDA coated liposomes as a tool in biomedical applications.
    Keywords
    Cell Physiology; Expanding Knowledge in the Chemical Sciences

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