Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms
Author
Ng, Ashley P.Date
2012Source Title
Leukemia and LymphomaPublisher
Informa HealthcareUniversity of Melbourne Author/s
Ng, AshleyAffiliation
Medicine, Dentistry & Health Sciences - Medical BiologyMetadata
Show full item recordDocument Type
Journal ArticleCitations
Ng, A. P. (2012). Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms. Leukemia and Lymphoma. doi: 10.3109/10428194.2012.734615Access Status
Open AccessDescription
Deposited with permission of the author. © 2012 Dr. Ashley P. Ng
This is a pre-print version, accepted for publication in Leukemia and Lymphoma © 2012, published by Informa Healthcare. http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734615?journalCode=lal
Abstract
The understanding of myeloproliferative neoplasms has changed dramatically since Dameshek proposed his classification over fifty years ago. Our knowledge of the types of cells which comprise the hematopoietic system and of how they are regulated has also appreciated significantly over this time. This review will relate what is currently known about the acquired genetic mutations associated with adult myeloproliferative neoplasms to how they lead to the hematopoietic perturbations of myeloproliferative disease. There will be a particular focus on how stem and progenitor cell compartments are affected by BCR-ABL1 and JAK2V617F mutations, and the particular issue of resistance of leukemic stem cells to conventional and targeted therapies.
Keywords
myeloproliferative neoplasms; stem and primitive progenitor cells; signal transductionExport Reference in RIS Format
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