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    Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms

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    Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms (4.941Mb)

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    2
    Author
    Ng, Ashley P.
    Date
    2012
    Source Title
    Leukemia and Lymphoma
    Publisher
    Informa Healthcare
    University of Melbourne Author/s
    Ng, Ashley
    Affiliation
    Medicine, Dentistry & Health Sciences - Medical Biology
    Metadata
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    Document Type
    Journal Article
    Citations
    Ng, A. P. (2012). Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms. Leukemia and Lymphoma. doi: 10.3109/10428194.2012.734615
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/32701
    DOI
    DOI: 10.3109/10428194.2012.734615 http://dx.doi.org/10.3109/10428194.2012.734615
    Description

    Deposited with permission of the author. © 2012 Dr. Ashley P. Ng

     

    This is a pre-print version, accepted for publication in Leukemia and Lymphoma © 2012, published by Informa Healthcare. http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734615?journalCode=lal

     
    Abstract
    The understanding of myeloproliferative neoplasms has changed dramatically since Dameshek proposed his classification over fifty years ago. Our knowledge of the types of cells which comprise the hematopoietic system and of how they are regulated has also appreciated significantly over this time. This review will relate what is currently known about the acquired genetic mutations associated with adult myeloproliferative neoplasms to how they lead to the hematopoietic perturbations of myeloproliferative disease. There will be a particular focus on how stem and progenitor cell compartments are affected by BCR-ABL1 and JAK2V617F mutations, and the particular issue of resistance of leukemic stem cells to conventional and targeted therapies.
    Keywords
    myeloproliferative neoplasms; stem and primitive progenitor cells; signal transduction

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