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    Scaling-up from an implementation trial to state-wide coverage: results from the preliminary Melbourne Diabetes Prevention Study

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    Scaling-up from an implementation trial to state-wide coverage: results from the preliminary Melbourne Diabetes Prevention Study (221.9Kb)

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    17
    12
    Author
    Janus, ED; Best, JD; Davis-Lameloise, N; Philpot, B; Hernan, A; Bennett, CM; O'Reilly, S; Carter, R; Vartiainen, E; Dunbar, JA
    Date
    2012-08-28
    Source Title
    TRIALS
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Janus, Edward; Best, James
    Affiliation
    Department of Medicine, North West Academic Centre, Western Hospital
    Melbourne Medical School
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Janus, E. D., Best, J. D., Davis-Lameloise, N., Philpot, B., Hernan, A., Bennett, C. M., O'Reilly, S., Carter, R., Vartiainen, E. & Dunbar, J. A. (2012). Scaling-up from an implementation trial to state-wide coverage: results from the preliminary Melbourne Diabetes Prevention Study. TRIALS, 13 (1), https://doi.org/10.1186/1745-6215-13-152.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/32741
    DOI
    10.1186/1745-6215-13-152
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502588
    Description

    © 2012 Janus et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract
    BACKGROUND: The successful Greater Green Triangle Diabetes Prevention Program (GGT DPP), a small implementation trial, has been scaled-up to the Victorian state-wide 'Life!' programme with over 10,000 individuals enrolled. The Melbourne Diabetes Prevention Study (MDPS) is an evaluation of the translation from the GGT DPP to the Life! programme. We report results from the preliminary phase (pMDPS) of this evaluation. METHODS: The pMDPS is a randomised controlled trial with 92 individuals aged 50 to 75 at high risk of developing type 2 diabetes randomised to Life! or usual care. Intervention consisted of six structured 90-minute group sessions: five fortnightly sessions and the final session at 8 months. Participants underwent anthropometric and laboratory tests at baseline and 12 months, and provided self-reported psychosocial, dietary, and physical activity measures. Intervention group participants additionally underwent these tests at 3 months. Paired t tests were used to analyse within-group changes over time. Chi-square tests were used to analyse differences between groups in goals met at 12 months. Differences between groups for changes over time were tested with generalised estimating equations and analysis of covariance. RESULTS: Intervention participants significantly improved at 12 months in mean body mass index (-0.98 kg/m(2), standard error (SE) = 0.26), weight (-2.65 kg, SE = 0.72), waist circumference (-7.45 cm, SE = 1.15), and systolic blood pressure (-3.18 mmHg, SE = 1.26), increased high-density lipoprotein-cholesterol (0.07 mmol/l, SE = 0.03), reduced energy from total (-2.00%, SE = 0.78) and saturated fat (-1.54%, SE = 0.41), and increased fibre intake (1.98 g/1,000 kcal energy, SE = 0.47). In controls, oral glucose at 2 hours deteriorated (0.59 mmol/l, SE = 0.27). Only waist circumference reduced significantly (-4.02 cm, SE = 0.95).Intervention participants significantly outperformed controls over 12 months for body mass index and fibre intake. After baseline adjustment, they also showed greater weight loss and reduced saturated fat versus total energy intake.At least 5% weight loss was achieved by 32% of intervention participants versus 0% controls. CONCLUSIONS: pMDPS results indicate that scaling-up from implementation trial to state-wide programme is possible. The system design for Life! was fit for purpose of scaling-up from efficacy to effectiveness. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry ACTRN12609000507280.
    Keywords
    type 2 diabetes; prevention; lifestyle; intervention; implementation; randomised controlled trial; effectiveness

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