University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Physiology
  • Physiology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Physiology
  • Physiology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    14
    11
    Author
    Tran, M; Gallo, LA; Wadley, GD; Jefferies, AJ; Moritz, KM; Wlodek, ME
    Date
    2012-09-13
    Source Title
    PLOS ONE
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Wadley, Glenn; Jefferies, Andrew; Wlodek, Mary; GALLO, LINDA; TRAN, MELANIE
    Affiliation
    Physiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tran, M., Gallo, L. A., Wadley, G. D., Jefferies, A. J., Moritz, K. M. & Wlodek, M. E. (2012). Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk. PLOS ONE, 7 (9), https://doi.org/10.1371/journal.pone.0045188.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/32821
    DOI
    10.1371/journal.pone.0045188
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441641
    Description

    C1 - Journal Articles Refereed

    Abstract
    There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancreatic function. The aim of this study was to determine whether growth restricted females develop long-term impairment of metabolic control after an adverse pregnancy adaptation. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) in late pregnancy (E18) in F0 female rats. F1 Control and Restricted female offspring were mated with normal males and allowed to deliver (termed Ex-Pregnant). Age-matched Control and Restricted Virgins were also studied and glucose tolerance and insulin secretion were determined. Pancreatic morphology and hepatic glycogen and triacylglycerol content were quantified respectively. Restricted females were born lighter than Control and remained lighter at all time points studied (p<0.05). Glucose tolerance, first phase insulin secretion and liver glycogen and triacylglycerol content were not different across groups, with no changes in β-cell mass. Second phase insulin secretion was reduced in Restricted Virgins (-34%, p<0.05) compared to Control Virgins, suggestive of enhanced peripheral insulin sensitivity but this was lost after pregnancy. Growth restriction was associated with enhanced basal hepatic insulin sensitivity, which may provide compensatory benefits to prevent adverse metabolic outcomes often associated with being born small. A prior pregnancy was associated with reduced hepatic insulin sensitivity with effects more pronounced in Controls than Restricted. Our data suggests that pregnancy ameliorates the enhanced peripheral insulin sensitivity in growth restricted females and has deleterious effects for hepatic insulin sensitivity, regardless of maternal birth weight.
    Keywords
    Foetal Development and Medicine; Reproductive System and Disorders

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52369]
    • Physiology - Research Publications [393]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors