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dc.contributor.authorGallo, LA
dc.contributor.authorTran, M
dc.contributor.authorMoritz, KM
dc.contributor.authorJefferies, AJ
dc.contributor.authorWlodek, ME
dc.date.available2014-05-22T07:12:39Z
dc.date.issued2012-10-01
dc.identifierpii: fj.12-210401
dc.identifier.citationGallo, L. A., Tran, M., Moritz, K. M., Jefferies, A. J. & Wlodek, M. E. (2012). Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth. FASEB JOURNAL, 26 (10), pp.4337-4347. https://doi.org/10.1096/fj.12-210401.
dc.identifier.issn0892-6638
dc.identifier.urihttp://hdl.handle.net/11343/32834
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractUteroplacental insufficiency is associated with adult cardiorenal and metabolic diseases, particularly in males. Pregnancy is the greatest physiological challenge facing women, and those born small are at increased risk of gestational hypertension and diabetes and delivering smaller babies. Increased maternal age is associated with exacerbated pregnancy complications. We hypothesized that pregnancy in aged, growth-restricted females unmasks an underlying predisposition to cardiorenal and metabolic dysfunction and compromises fetal growth. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (restricted group) or sham surgery (control group) on d 18 of gestation in Wistar Kyoto rats. At 12 mo, growth-restricted F1 female offspring were mated with a normal male. F1 restricted females had elevated systolic blood pressure, before and during pregnancy (+10 mmHg) but normal renal and metabolic pregnancy adaptations. F2 fetal weight was not different between groups. In control and restricted females, advanced maternal age (12 vs. 4 mo) was associated with a reduction in the hypoglycemic response to pregnancy and reduced F2 fetal litter size and body weight. Aged rats born small exhibited mostly normal pregnancy adaptations, although they had elevated blood pressure. Advanced maternal age was associated with poorer fetal outcomes that were not exacerbated by low maternal birth weight.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherFEDERATION AMER SOC EXP BIOL
dc.subjectFoetal Development and Medicine; Reproductive System and Disorders
dc.titlePregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth
dc.typeJournal Article
dc.identifier.doi10.1096/fj.12-210401
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPhysiology
melbourne.source.titleThe FASEB Journal
melbourne.source.volume26
melbourne.source.issue10
melbourne.source.pages4337-4347
melbourne.identifier.nhmrc400004
melbourne.publicationid185010
melbourne.elementsid371020
melbourne.contributor.authorJefferies, Andrew
melbourne.contributor.authorWlodek, Mary
melbourne.contributor.authorTRAN, MELANIE
melbourne.contributor.authorGALLO, LINDA
dc.identifier.eissn1530-6860
melbourne.identifier.fundernameidNHMRC, 400004
melbourne.fieldofresearch321501 Foetal development and medicine
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository


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