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    Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventrolateral Medulla Modulate the Pressor Response to Aversive Stress

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    Author
    Chen, D; Jancovski, N; Bassi, JK; Thu-Phuc, N-H; Choong, Y-T; Palma-Rigo, K; Davern, PJ; Gurley, SB; Thomas, WG; Head, GA; ...
    Date
    2012-02-08
    Source Title
    JOURNAL OF NEUROSCIENCE
    Publisher
    SOC NEUROSCIENCE
    University of Melbourne Author/s
    Bassi, Jaspreet; Allen, Andrew; Choong, Yan Ting; CHEN, DAIAN; Jancovski, Nikola
    Affiliation
    Physiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Chen, D., Jancovski, N., Bassi, J. K., Thu-Phuc, N. -H., Choong, Y. -T., Palma-Rigo, K., Davern, P. J., Gurley, S. B., Thomas, W. G., Head, G. A. & Allen, A. M. (2012). Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventrolateral Medulla Modulate the Pressor Response to Aversive Stress. JOURNAL OF NEUROSCIENCE, 32 (6), pp.2051-2061. https://doi.org/10.1523/JNEUROSCI.5360-11.2012.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/32836
    DOI
    10.1523/JNEUROSCI.5360-11.2012
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621685
    Description

    C1 - Journal Articles Refereed

    Abstract
    The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A receptors (AT(1A)Rs) at various sites within the brain, including the rostral ventrolateral medulla. In this study we examine the involvement of AT(1A)Rs associated with a subclass of sympathetic premotor neurons of the rostral ventrolateral medulla, the C1 neurons. The distribution of putative AT(1A)R-expressing cells was mapped throughout the brains of three transgenic mice with a bacterial artificial chromosome-expressing green fluorescent protein under the control of the AT(1A)R promoter. The overall distribution correlated with that of the AT(1A)Rs mapped by other methods and demonstrated that the majority of C1 neurons express the AT(1A)R. Cre-recombinase expression in C1 neurons of AT(1A)R-floxed mice enabled demonstration that the pressor response to microinjection of angiotensin II into the rostral ventrolateral medulla is dependent upon expression of the AT(1A)R in these neurons. Lentiviral-induced expression of wild-type AT(1A)Rs in C1 neurons of global AT(1A)R knock-out mice, implanted with radiotelemeter devices for recording blood pressure, modulated the pressor response to aversive stress. During prolonged cage-switch stress, expression of AT(1A)Rs in C1 neurons induced a greater sustained pressor response when compared to the control viral-injected group (22 ± 4 mmHg for AT(1A)R vs 10 ± 1 mmHg for GFP; p < 0.001), which was restored toward that of the wild-type group (28 ± 2 mmHg). This study demonstrates that AT(1A)R expression by C1 neurons is essential for the pressor response to angiotensin II and that this pathway plays an important role in the pressor response to aversive stress.
    Keywords
    Cardiology (incl. Cardiovascular Diseases); Autonomic Nervous System; Expanding Knowledge in the Medical and Health Sciences

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