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dc.contributor.authorEastwood, A
dc.contributor.authorSharpe, K
dc.contributor.authorBourdon, PC
dc.contributor.authorWoolford, SM
dc.contributor.authorSaunders, PU
dc.contributor.authorRobertson, EY
dc.contributor.authorClark, SA
dc.contributor.authorGore, CJ
dc.date.available2014-05-22T07:15:57Z
dc.date.issued2012-04-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301897200020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationEastwood, A., Sharpe, K., Bourdon, P. C., Woolford, S. M., Saunders, P. U., Robertson, E. Y., Clark, S. A. & Gore, C. J. (2012). Within-Subject Variation in Hemoglobin Mass in Elite Athletes. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44 (4), pp.725-732. https://doi.org/10.1249/MSS.0b013e318238ea7f.
dc.identifier.issn0195-9131
dc.identifier.urihttp://hdl.handle.net/11343/32852
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractUNLABELLED: Illicit autologous blood transfusion to improve performance in elite sport is currently undetectable, but the stability of longitudinal profiles of an athlete's hemoglobin mass (Hbmass) might be used to detect such practices. PURPOSE: Our aim was to quantify within-subject variation of Hbmass in elite athletes, and the effects of potentially confounding factors such as reduced training or altitude exposure. METHODS: A total of 130 athletes (43 females and 87 males) were measured for Hbmass an average of six times during a period of approximately 1 yr using carbon monoxide rebreathing. Linear mixed models were used to quantify within-subject variation of Hbmass and its associated analytical and biological components for males and females, as well as the effects of reduced training and moderate altitude exposure in certain athletes. RESULTS: The maximum within-subject coefficient of variation (CV) for Hbmass was 3.4% for males and 4.0% for females. The analytical CV was ~2.0% for both males and females, and the long-term biological CV, after allowing for analytical variation, was 2.8% for males and 3.5% for females. On average, self-reported reduced training resulted in a 2.8% decrease in Hbmass and altitude exposure increased Hbmass by 1.5% to 2.9%, depending on the duration and type of exposure. CONCLUSIONS: The within-subject CV for Hbmass of ~4% indicates that athletes may experience changes up to ~20% with a 1-in-1000 probability. Changes of this magnitude for measures taken a few months apart suggest that Hbmass has a limited capacity to detect autologous blood doping. However, changes in Hbmass may be a useful indicator when combined with other measures of blood manipulation.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectSports Medicine; Organised Sports
dc.titleWithin-Subject Variation in Hemoglobin Mass in Elite Athletes
dc.typeJournal Article
dc.identifier.doi10.1249/MSS.0b013e318238ea7f
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMathematics And Statistics
melbourne.source.titleMEDICINE AND SCIENCE IN SPORTS AND EXERCISE
melbourne.source.volume44
melbourne.source.issue4
melbourne.source.pages725-732
melbourne.publicationid188943
melbourne.elementsid398137
melbourne.contributor.authorSharpe, Kenneth
dc.identifier.eissn1530-0315
melbourne.fieldofresearch320225 Sports medicine
melbourne.seocode130602 Organised sports
melbourne.accessrightsThis item is currently not available from this repository


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