University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    13
    11
    Author
    Brotherton, JML; Tabrizi, SN; Garland, SM
    Date
    2012-02-01
    Source Title
    FUTURE MICROBIOLOGY
    Publisher
    FUTURE MEDICINE LTD
    University of Melbourne Author/s
    Wark, Suzanne; Tabrizi, Sepehr
    Affiliation
    Obstetrics And Gynaecology Royal Women'S Hospital/Mercy
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Brotherton, J. M. L., Tabrizi, S. N. & Garland, S. M. (2012). Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance. FUTURE MICROBIOLOGY, 7 (2), pp.193-199. https://doi.org/10.2217/FMB.11.161.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/32853
    DOI
    10.2217/FMB.11.161
    Description

    C1 - Journal Articles Refereed

    Abstract
    AIM: We used existing data to investigate whether prevalence of HPV16/18 in cervical intraepithelial neoplasia 3 (CIN3) varies by age, in order to determine whether age specific baseline data is required as the prevaccination comparator for type-specific surveillance following HPV vaccination programs. MATERIALS & METHODS: We analyzed available Australian HPV typing data from 317 cervical smears from women with concurrent CIN3 on biopsy and conducted a review and analysis of the international literature. RESULTS: Among 317 women with CIN3, HPV16 was detected in 70% of those 16-25 years old, 59% of 26-35-year-olds and 48% of >36-year-olds (p = 0.025). This association took the form of a trend with decreasing HPV16 prevalence with increasing age (p = 0.007). That HPV16 is commoner in younger women with high-grade cervical lesions was consistent with all but one study of 18 identified in the literature. CONCLUSION: In screened populations, younger women with CIN3 are more likely to have HPV16 detected. To make valid pre- and post-vaccination comparisons, surveillance specimens for HPV typing should be both age stratified and lesion specific.
    Keywords
    Oncology and Carcinogenesis not elsewhere classified; Infectious Diseases

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Obstetrics and Gynaecology - Research Publications [649]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors