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dc.contributor.authorBrotherton, JML
dc.contributor.authorTabrizi, SN
dc.contributor.authorGarland, SM
dc.identifier.citationBrotherton, J. M. L., Tabrizi, S. N. & Garland, S. M. (2012). Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance. FUTURE MICROBIOLOGY, 7 (2), pp.193-199.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractAIM: We used existing data to investigate whether prevalence of HPV16/18 in cervical intraepithelial neoplasia 3 (CIN3) varies by age, in order to determine whether age specific baseline data is required as the prevaccination comparator for type-specific surveillance following HPV vaccination programs. MATERIALS & METHODS: We analyzed available Australian HPV typing data from 317 cervical smears from women with concurrent CIN3 on biopsy and conducted a review and analysis of the international literature. RESULTS: Among 317 women with CIN3, HPV16 was detected in 70% of those 16-25 years old, 59% of 26-35-year-olds and 48% of >36-year-olds (p = 0.025). This association took the form of a trend with decreasing HPV16 prevalence with increasing age (p = 0.007). That HPV16 is commoner in younger women with high-grade cervical lesions was consistent with all but one study of 18 identified in the literature. CONCLUSION: In screened populations, younger women with CIN3 are more likely to have HPV16 detected. To make valid pre- and post-vaccination comparisons, surveillance specimens for HPV typing should be both age stratified and lesion specific.
dc.subjectOncology and Carcinogenesis not elsewhere classified; Infectious Diseases
dc.titleDoes HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentObstetrics And Gynaecology Royal Women'S Hospital/Mercy
melbourne.source.titleFuture Microbiology
melbourne.contributor.authorWark, Suzanne
melbourne.contributor.authorTabrizi, Sepehr
melbourne.contributor.authorBrotherton, Julia
melbourne.fieldofresearch321199 Oncology and carcinogenesis not elsewhere classified
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

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