dc.contributor.author | Brotherton, JML | |
dc.contributor.author | Tabrizi, SN | |
dc.contributor.author | Garland, SM | |
dc.date.available | 2014-05-22T07:16:08Z | |
dc.date.issued | 2012-02-01 | |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300277900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c | |
dc.identifier.citation | Brotherton, J. M. L., Tabrizi, S. N. & Garland, S. M. (2012). Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance. FUTURE MICROBIOLOGY, 7 (2), pp.193-199. https://doi.org/10.2217/FMB.11.161. | |
dc.identifier.issn | 1746-0913 | |
dc.identifier.uri | http://hdl.handle.net/11343/32853 | |
dc.description | C1 - Journal Articles Refereed | |
dc.description.abstract | AIM: We used existing data to investigate whether prevalence of HPV16/18 in cervical intraepithelial neoplasia 3 (CIN3) varies by age, in order to determine whether age specific baseline data is required as the prevaccination comparator for type-specific surveillance following HPV vaccination programs. MATERIALS & METHODS: We analyzed available Australian HPV typing data from 317 cervical smears from women with concurrent CIN3 on biopsy and conducted a review and analysis of the international literature. RESULTS: Among 317 women with CIN3, HPV16 was detected in 70% of those 16-25 years old, 59% of 26-35-year-olds and 48% of >36-year-olds (p = 0.025). This association took the form of a trend with decreasing HPV16 prevalence with increasing age (p = 0.007). That HPV16 is commoner in younger women with high-grade cervical lesions was consistent with all but one study of 18 identified in the literature. CONCLUSION: In screened populations, younger women with CIN3 are more likely to have HPV16 detected. To make valid pre- and post-vaccination comparisons, surveillance specimens for HPV typing should be both age stratified and lesion specific. | |
dc.language | English | |
dc.publisher | FUTURE MEDICINE LTD | |
dc.subject | Oncology and Carcinogenesis not elsewhere classified; Infectious Diseases | |
dc.title | Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance | |
dc.type | Journal Article | |
dc.identifier.doi | 10.2217/FMB.11.161 | |
melbourne.peerreview | Peer Reviewed | |
melbourne.affiliation | The University of Melbourne | |
melbourne.affiliation.department | Obstetrics And Gynaecology Royal Women'S Hospital/Mercy | |
melbourne.source.title | FUTURE MICROBIOLOGY | |
melbourne.source.volume | 7 | |
melbourne.source.issue | 2 | |
melbourne.source.pages | 193-199 | |
dc.research.codefor | 111299 | |
dc.research.codeseo2008 | 920109 | |
melbourne.publicationid | 176559 | |
melbourne.elementsid | 408742 | |
melbourne.contributor.author | Wark, Suzanne | |
melbourne.contributor.author | Tabrizi, Sepehr | |
dc.identifier.eissn | 1746-0921 | |
melbourne.fieldofresearch | 321199 Oncology and carcinogenesis not elsewhere classified | |
melbourne.seocode | 200199 Clinical health not elsewhere classified | |
melbourne.accessrights | This item is currently not available from this repository | |