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dc.contributor.authorBrotherton, JML
dc.contributor.authorTabrizi, SN
dc.contributor.authorGarland, SM
dc.date.available2014-05-22T07:16:08Z
dc.date.issued2012-02-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300277900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationBrotherton, J. M. L., Tabrizi, S. N. & Garland, S. M. (2012). Does HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance. FUTURE MICROBIOLOGY, 7 (2), pp.193-199. https://doi.org/10.2217/FMB.11.161.
dc.identifier.issn1746-0913
dc.identifier.urihttp://hdl.handle.net/11343/32853
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractAIM: We used existing data to investigate whether prevalence of HPV16/18 in cervical intraepithelial neoplasia 3 (CIN3) varies by age, in order to determine whether age specific baseline data is required as the prevaccination comparator for type-specific surveillance following HPV vaccination programs. MATERIALS & METHODS: We analyzed available Australian HPV typing data from 317 cervical smears from women with concurrent CIN3 on biopsy and conducted a review and analysis of the international literature. RESULTS: Among 317 women with CIN3, HPV16 was detected in 70% of those 16-25 years old, 59% of 26-35-year-olds and 48% of >36-year-olds (p = 0.025). This association took the form of a trend with decreasing HPV16 prevalence with increasing age (p = 0.007). That HPV16 is commoner in younger women with high-grade cervical lesions was consistent with all but one study of 18 identified in the literature. CONCLUSION: In screened populations, younger women with CIN3 are more likely to have HPV16 detected. To make valid pre- and post-vaccination comparisons, surveillance specimens for HPV typing should be both age stratified and lesion specific.
dc.languageEnglish
dc.publisherFUTURE MEDICINE LTD
dc.subjectOncology and Carcinogenesis not elsewhere classified; Infectious Diseases
dc.titleDoes HPV type 16 or 18 prevalence in cervical intraepithelial neoplasia grade 3 lesions vary by age? An important issue for postvaccination surveillance
dc.typeJournal Article
dc.identifier.doi10.2217/FMB.11.161
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentObstetrics And Gynaecology Royal Women'S Hospital/Mercy
melbourne.source.titleFuture Microbiology
melbourne.source.volume7
melbourne.source.issue2
melbourne.source.pages193-199
melbourne.publicationid176559
melbourne.elementsid408742
melbourne.contributor.authorWark, Suzanne
melbourne.contributor.authorTabrizi, Sepehr
melbourne.contributor.authorBrotherton, Julia
dc.identifier.eissn1746-0921
melbourne.fieldofresearch321199 Oncology and carcinogenesis not elsewhere classified
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository


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