University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Radiology
  • Radiology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Radiology
  • Radiology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    24
    17
    Author
    Tescher, P; Macrae, FA; Speer, T; Stella, D; Gibson, R; Tye-Din, JA; Srivatsa, G; Jones, IT; Marion, K
    Date
    2010-04-04
    Source Title
    HEREDITARY CANCER IN CLINICAL PRACTICE
    Publisher
    BMC
    University of Melbourne Author/s
    Tye Din, Jason; Macrae, Finlay; Jones, Ian; Stella, Damien; Speer, Antony; Gibson, Robert; SRIVATSA, GEETA; TESCHER, PAUL MICHAEL; Marion, Kaye; Tye-Din, Jason
    Affiliation
    Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tescher, P., Macrae, F. A., Speer, T., Stella, D., Gibson, R., Tye-Din, J. A., Srivatsa, G., Jones, I. T. & Marion, K. (2010). Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps. HEREDITARY CANCER IN CLINICAL PRACTICE, 8 (1), https://doi.org/10.1186/1897-4287-8-3.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/32918
    DOI
    10.1186/1897-4287-8-3
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859487
    Description

    C1 - Journal Articles Refereed

    Abstract
    BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract. Information on adenoma status below the duodenum has previously been restricted due to its inaccessibility in vivo. Capsule Endoscopy (CE) may provide a useful adjunct in screening for polyposis in the small bowel in FAP patients. This study aims to evaluate the effectiveness of CE in the assessment of patients with FAP, compared to other imaging modalities for the detection of small bowel polyps. METHOD: 20 consecutive patients with previously diagnosed FAP and duodenal polyps, presenting for routine surveillance of polyps at The Royal Melbourne Hospital were recruited. Each fasted patient initially underwent a magnetic resonance image (MRI) of the abdomen, and a barium small bowel follow-through study. Capsule Endoscopy was performed four weeks later on the fasted patient. An upper gastrointestinal side-viewing endoscopy was done one (1) to two (2) weeks after this. Endoscopists and investigators were blinded to results of other investigations and patient history. RESULTS: Within the stomach, upper gastrointestinal endoscopy found more polyps than other forms of imaging. SBFT and MRI generally performed poorly, identifying fewer polyps than both upper gastrointestinal and capsule endoscopy. CE was the only form of imaging that identified polyps in all segments of the small bowel as well as the only form of imaging able to provide multiple findings outside the stomach/duodenum. CONCLUSION: CE provides important information on possible polyp development distal to the duodenum, which may lead to surgical intervention. The place of CE as an adjunct in surveillance of FAP for a specific subset needs consideration and confirmation in replication studies. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12608000616370.
    Keywords
    Gastroenterology and Hepatology; Radiology and Organ Imaging; Diagnostic Methods

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Radiology - Research Publications [114]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors