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    Investigation of Ocular Hemodynamics in Sturge-Weber Syndrome

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    3
    Author
    Conway, M; Hosking, SL
    Date
    2012-06-01
    Source Title
    OPTOMETRY AND VISION SCIENCE
    Publisher
    LIPPINCOTT WILLIAMS & WILKINS
    University of Melbourne Author/s
    HOSKING, SARAH
    Affiliation
    Optometry And Vision Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Conway, M. & Hosking, S. L. (2012). Investigation of Ocular Hemodynamics in Sturge-Weber Syndrome. OPTOMETRY AND VISION SCIENCE, 89 (6), pp.922-928. https://doi.org/10.1097/OPX.0b013e318257a242.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/32935
    DOI
    10.1097/OPX.0b013e318257a242
    Description

    C1 - Journal Articles Refereed

    Abstract
    PURPOSE: Sturge-Weber syndrome (SWS) is a condition often associated with facial cutaneous angioma, vascular malformations in the brain, and ocular anomalies such as glaucoma. Reduced cerebral blood flow and ischemia have been well documented. Less is known about ocular blood flow despite the frequent associations between altered hemodynamics and the mechanisms underlying glaucomatous optic neuropathy. The aim of this research was to investigate retrobulbar hemodynamics in patients diagnosed with SWS. METHODS: The sample comprised 16 patients diagnosed with SWS and 16 age- and gender-matched normal control subjects. Four patients were diagnosed with both SWS and primary open-angle glaucoma (mean age 34.3 years; SD 26.9 years), three patients with both SWS and closed-angle glaucoma (mean age 23.3 years; SD 18.0 years), and nine patients with SWS and no glaucoma (mean age 17.2 years; SD 9.1 years). Systemic blood pressure and intraocular pressure were measured to determine the mean arterial pressure and ocular perfusion pressure. All patients and subjects underwent ultrasonography of the ophthalmic artery, central retinal artery, and short posterior ciliary arteries. RESULTS: No significant difference between groups for mean arterial pressure or ocular perfusion pressure (p > 0.05) was recorded. Participants diagnosed with SWS and primary open-angle glaucoma showed significantly reduced end-diastolic velocity (mean 0.036 m/s; SD 0.005 m/s) in their central retinal artery (p = 0.016) when compared against their age-matched normal controls (mean 0.054 m/s; SD 0.010 m/s). Participants diagnosed with SWS and no glaucoma also showed significantly reduced end-diastolic velocity (mean 0.038 m/s; SD 0.015 m/s) in their central retinal artery (p = 0.046) when compared against their age-matched normal controls (mean 0.054 m/s; SD 0.014 m/s). CONCLUSIONS: Retrobulbar hemodynamics appear to be altered in participants diagnosed with SWS irrespective of their diagnosis of glaucoma. Further research is needed to ascertain whether there are any long-term consequences of such changes to ocular physiology.
    Keywords
    Sensory Systems; Hearing; Vision; Speech and Their Disorders

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