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    Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis

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    Author
    Wong, RCS; Cloherty, SL; Ibbotson, MR; O'Brien, BJ
    Date
    2012-10-01
    Source Title
    JOURNAL OF NEUROPHYSIOLOGY
    Publisher
    AMER PHYSIOLOGICAL SOC
    University of Melbourne Author/s
    CLOHERTY, SHAUN; Ibbotson, Michael
    Affiliation
    Optometry And Vision Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Wong, R. C. S., Cloherty, S. L., Ibbotson, M. R. & O'Brien, B. J. (2012). Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis. JOURNAL OF NEUROPHYSIOLOGY, 108 (7), pp.2008-2023. https://doi.org/10.1152/jn.01091.2011.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/32936
    DOI
    10.1152/jn.01091.2011
    NHMRC Grant code
    NHMRC/585440
    Description

    C1 - Journal Articles Refereed

    Abstract
    Mammalian retina contains 15-20 different retinal ganglion cell (RGC) types, each of which is responsible for encoding different aspects of the visual scene. The encoding is defined by a combination of RGC synaptic inputs, the neurotransmitter systems used, and their intrinsic physiological properties. Each cell's intrinsic properties are defined by its morphology and membrane characteristics, including the complement and localization of the ion channels expressed. In this study, we examined the hypothesis that the intrinsic properties of individual RGC types are conserved among mammalian species. To do so, we measured the intrinsic properties of 16 morphologically defined rat RGC types and compared these data with cat RGC types. Our data demonstrate that in the rat different morphologically defined RGC types have distinct patterns of intrinsic properties. Variation in these properties across cell types was comparable to that found for cat RGC types. When presumed morphological homologs in rat and cat retina were compared directly, some RGC types had very similar properties. The rat A2 cell exhibited patterns of intrinsic properties nearly identical to the cat alpha cell. In contrast, rat D2 cells (ON-OFF directionally selective) had a very different pattern of intrinsic properties than the cat iota cell. Our data suggest that the intrinsic properties of RGCs with similar morphology and suspected visual function may be subject to variation due to the behavioral needs of the species.
    Keywords
    Sensory Systems; Hearing; Vision; Speech and Their Disorders

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