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dc.contributor.authorHuntjens, B
dc.contributor.authorCharman, WN
dc.contributor.authorWorkman, H
dc.contributor.authorHosking, SL
dc.contributor.authorO'Donnell, C
dc.date.available2014-05-22T07:34:11Z
dc.date.available2012-11-26
dc.date.issued2012-12-28
dc.identifierpii: PONE-D-12-20933
dc.identifier.citationHuntjens, B., Charman, W. N., Workman, H., Hosking, S. L. & O'Donnell, C. (2012). Short-Term Stability in Refractive Status Despite Large Fluctuations in Glucose Levels in Diabetes Mellitus Type 1 and 2. PLOS ONE, 7 (12), https://doi.org/10.1371/journal.pone.0052947.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/32953
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractPURPOSE: This work investigates how short-term changes in blood glucose concentration affect the refractive components of the diabetic eye in patients with long-term Type 1 and Type 2 diabetes. METHODS: Blood glucose concentration, refractive error components (mean spherical equivalent MSE, J0, J45), central corneal thickness (CCT), anterior chamber depth (ACD), crystalline lens thickness (LT), axial length (AL) and ocular aberrations were monitored at two-hourly intervals over a 12-hour period in: 20 T1DM patients (mean age ± SD) 38±14 years, baseline HbA1c 8.6±1.9%; 21 T2DM patients (mean age ± SD) 56±11 years, HbA1c 7.5±1.8%; and in 20 control subjects (mean age ± SD) 49±23 years, HbA1c 5.5±0.5%. The refractive and biometric results were compared with the corresponding changes in blood glucose concentration. RESULTS: Blood glucose concentration at different times was found to vary significantly within (p<0.0005) and between groups (p<0.0005). However, the refractive error components and ocular aberrations were not found to alter significantly over the day in either the diabetic patients or the control subjects (p>0.05). Minor changes of marginal statistical or optical significance were observed in some biometric parameters. Similarly there were some marginally significant differences between the baseline biometric parameters of well-controlled and poorly-controlled diabetic subjects. CONCLUSION: This work suggests that normal, short-term fluctuations (of up to about 6 mM/l on a timescale of a few hours) in the blood glucose levels of diabetics are not usually associated with acute changes in refractive error or ocular wavefront aberrations. It is therefore possible that factors other than refractive error fluctuations are sometimes responsible for the transient visual problems often reported by diabetic patients.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.subjectSensory Systems; Hearing
dc.subjectVision
dc.subjectSpeech and Their Disorders
dc.titleShort-Term Stability in Refractive Status Despite Large Fluctuations in Glucose Levels in Diabetes Mellitus Type 1 and 2
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0052947
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentOptometry And Vision Sciences
melbourne.source.titlePLOS ONE
melbourne.source.volume7
melbourne.source.issue12
dc.research.codefor110906
dc.research.codeseo2008920107
dc.rights.licenseCC BY
melbourne.publicationid193351
melbourne.elementsid493074
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532445
melbourne.contributor.authorHOSKING, SARAH
dc.identifier.eissn1932-6203
melbourne.conference.locationUnited States
pubs.acceptance.date2012-11-26
melbourne.accessrightsAccess this item via the Open Access location


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