Glial and neuronal dysfunction in streptozotocin-induced diabetic rats.
Author
Wong, VHY; Vingrys, AJ; Bui, BVDate
2011-06Source Title
J Ocul Biol Dis InforPublisher
Springer Science and Business Media LLCAffiliation
Optometry And Vision SciencesMetadata
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Journal ArticleCitations
Wong, V. H. Y., Vingrys, A. J. & Bui, B. V. (2011). Glial and neuronal dysfunction in streptozotocin-induced diabetic rats.. J Ocul Biol Dis Infor, 4 (1-2), pp.42-50. https://doi.org/10.1007/s12177-011-9069-3.Access Status
Access this item via the Open Access locationOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342402Description
C1 - Journal Articles Refereed
Abstract
Neuronal dysfunction has been noted very soon after the induction of diabetes by streptozotocin injection in rats. It is not clear from anatomical evidence whether glial cell dysfunction accompanies the well-documented neuronal deficit. Here, we isolate the Müller cell driven slow-P3 component of the full-field electroretinogram and show that it is attenuated at 4 weeks following the onset of streptozotocin-hyperglycaemia. We also found a concurrent reduction in the sensitivity of the phototransduction cascade, as well as in the components of the electroretinogram known to indicate retinal ganglion cell and amacrine cell integrity. Our data support the idea that neuronal and Müller cell dysfunction occurs at the same time in streptozotocin-induced hyperglycaemia.
Keywords
Optometry and Ophthalmology not elsewhere classified; Diabetes; Hearing; Vision; Speech and Their DisordersExport Reference in RIS Format
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