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    Glial and neuronal dysfunction in streptozotocin-induced diabetic rats.

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    11
    Author
    Wong, VHY; Vingrys, AJ; Bui, BV
    Date
    2011-06
    Source Title
    J Ocul Biol Dis Infor
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    WONG, VICKIE; Vingrys, Algis; Bui, Bang; Wong, Vickie; Cole, Barry
    Affiliation
    Optometry And Vision Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Wong, V. H. Y., Vingrys, A. J. & Bui, B. V. (2011). Glial and neuronal dysfunction in streptozotocin-induced diabetic rats.. J Ocul Biol Dis Infor, 4 (1-2), pp.42-50. https://doi.org/10.1007/s12177-011-9069-3.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/32955
    DOI
    10.1007/s12177-011-9069-3
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342402
    Description

    C1 - Journal Articles Refereed

    Abstract
    Neuronal dysfunction has been noted very soon after the induction of diabetes by streptozotocin injection in rats. It is not clear from anatomical evidence whether glial cell dysfunction accompanies the well-documented neuronal deficit. Here, we isolate the Müller cell driven slow-P3 component of the full-field electroretinogram and show that it is attenuated at 4 weeks following the onset of streptozotocin-hyperglycaemia. We also found a concurrent reduction in the sensitivity of the phototransduction cascade, as well as in the components of the electroretinogram known to indicate retinal ganglion cell and amacrine cell integrity. Our data support the idea that neuronal and Müller cell dysfunction occurs at the same time in streptozotocin-induced hyperglycaemia.
    Keywords
    Optometry and Ophthalmology not elsewhere classified; Diabetes; Hearing; Vision; Speech and Their Disorders

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