Glial and neuronal dysfunction in streptozotocin-induced diabetic rats.
AuthorWong, VHY; Vingrys, AJ; Bui, BV
Source TitleJ Ocul Biol Dis Infor
AffiliationOptometry And Vision Sciences
Document TypeJournal Article
CitationsWong, VHY; Vingrys, AJ; Bui, BV, Glial and neuronal dysfunction in streptozotocin-induced diabetic rats., J Ocul Biol Dis Infor, 2011, 4 (1-2), pp. 42 - 50
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342402
C1 - Journal Articles Refereed
Neuronal dysfunction has been noted very soon after the induction of diabetes by streptozotocin injection in rats. It is not clear from anatomical evidence whether glial cell dysfunction accompanies the well-documented neuronal deficit. Here, we isolate the Müller cell driven slow-P3 component of the full-field electroretinogram and show that it is attenuated at 4 weeks following the onset of streptozotocin-hyperglycaemia. We also found a concurrent reduction in the sensitivity of the phototransduction cascade, as well as in the components of the electroretinogram known to indicate retinal ganglion cell and amacrine cell integrity. Our data support the idea that neuronal and Müller cell dysfunction occurs at the same time in streptozotocin-induced hyperglycaemia.
KeywordsOptometry and Ophthalmology not elsewhere classified; Diabetes; Hearing; Vision; Speech and Their Disorders
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