Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008-2010
AuthorOctavia, S; Sintchenko, V; Gilbert, GL; Lawrence, A; Keil, AD; Hogg, G; Lan, R
Source TitleJOURNAL OF INFECTIOUS DISEASES
PublisherOXFORD UNIV PRESS INC
University of Melbourne Author/sHOGG, GEOFFREY
Document TypeJournal Article
CitationsOctavia, S., Sintchenko, V., Gilbert, G. L., Lawrence, A., Keil, A. D., Hogg, G. & Lan, R. (2012). Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008-2010. JOURNAL OF INFECTIOUS DISEASES, 205 (8), pp.1220-1224. https://doi.org/10.1093/infdis/jis178.
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C1 - Journal Articles Refereed
Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.
KeywordsPublic Health and Health Services not elsewhere classified; Public Health (excl. Specific Population Health) not elsewhere classified
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