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    Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice

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    Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice (103.1Kb)

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    Author
    Bird, MK; Kirchhoff, J; Djouma, E; Lawrence, AJ
    Date
    2008-09-01
    Source Title
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    Publisher
    CAMBRIDGE UNIV PRESS
    University of Melbourne Author/s
    Lawrence, Andrew
    Affiliation
    Centre for Neuroscience
    Metadata
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    Document Type
    Journal Article
    Citations
    Bird, M. K., Kirchhoff, J., Djouma, E. & Lawrence, A. J. (2008). Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11 (6), pp.765-774. https://doi.org/10.1017/S1461145708008572.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/32971
    DOI
    10.1017/S1461145708008572
    Description

    © 2008 CINP. Online edition of the journal is available at http://journals.cambridge.org/action/displayJournal?jid=PNP

    Abstract
    The metabotropic glutamate receptor 5 (mGlu5) has been implicated in ethanol- and drug-seeking behaviours in rodent studies. Here we examine a number of ethanol-related behavioural assays in mice lacking mGlu5 and wild-type littermates. In a two-bottle free-choice paradigm, mGlu5-deficient mice consumed less ethanol with a reduced preference compared to wild-type mice. Indeed, mGlu5-deficienct mice were ethanol-avoiding at both concentrations of ethanol proffered (5% and 10% v/v). However, there was no difference in the rate of hepatic ethanol and acetaldehyde metabolism between genotypes and consumption of saccharin was similar. In a conditioned place preference study, mGlu5-deficient mice displayed a place preference for ethanol when conditioned with a low dose (1g/kg) of ethanol. Thus, while mGlu5-deficient mice consume less ethanol (with a reduced preference) than wild-type mice, this is not apparently related to impaired hepatic metabolism or a lack of reward from ethanol. Rather, we provide evidence that deletion of the mGlu5 receptor increases sensitivity to centrally mediated effects of ethanol.
    Keywords
    alcohol consumption; mGlu5 receptor; mice; place preference; reward.

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