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    Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography

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    Author
    Bivard, A; McElduff, P; Spratt, N; Levi, C; Parsons, M
    Date
    2011-01-01
    Source Title
    CEREBROVASCULAR DISEASES
    Publisher
    KARGER
    University of Melbourne Author/s
    Bivard, Andrew
    Affiliation
    Medicine - Royal Melbourne Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Bivard, A., McElduff, P., Spratt, N., Levi, C. & Parsons, M. (2011). Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography. CEREBROVASCULAR DISEASES, 31 (3), pp.238-245. https://doi.org/10.1159/000321897.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/32988
    DOI
    10.1159/000321897
    Description

    C1 - Journal Articles Refereed

    Abstract
    BACKGROUND: Perfusion computed tomography (PCT) shows promise in acute stroke assessment. However, the accuracy of CT perfusion thresholds in defining the acute infarct core remains uncertain. METHOD: Concurrent PCT and MRI-DWI performed 3-6 h after symptoms onset were assessed in 57 ischemic stroke patients. PCT was compared to DWI images to define the infarct core using a pixel-based receiver operating characteristic curve analysis to calculate the area under the curve (AUC) for thresholds from PCT maps that were co-registered with the DWI slice location. RESULTS: A relative cerebral blood flow (CBF) of 45% of the contralateral hemisphere was found to be the most accurate threshold for describing the infarct core (AUC 0.788), and it was also by far the most frequent threshold with the highest AUC across patients. CONCLUSION: CBF thresholds on PCT define the acute infarct core more accurately than do other PCT thresholds, including a cerebral blood volume of 2 ml/100 g.
    Keywords
    Neurology and Neuromuscular Diseases; Nervous System and Disorders

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