Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography
Author
Bivard, A; McElduff, P; Spratt, N; Levi, C; Parsons, MDate
2011-01-01Source Title
CEREBROVASCULAR DISEASESPublisher
KARGERUniversity of Melbourne Author/s
Bivard, AndrewAffiliation
Medicine - Royal Melbourne HospitalMetadata
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Journal ArticleCitations
Bivard, A., McElduff, P., Spratt, N., Levi, C. & Parsons, M. (2011). Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography. CEREBROVASCULAR DISEASES, 31 (3), pp.238-245. https://doi.org/10.1159/000321897.Access Status
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C1 - Journal Articles Refereed
Abstract
BACKGROUND: Perfusion computed tomography (PCT) shows promise in acute stroke assessment. However, the accuracy of CT perfusion thresholds in defining the acute infarct core remains uncertain. METHOD: Concurrent PCT and MRI-DWI performed 3-6 h after symptoms onset were assessed in 57 ischemic stroke patients. PCT was compared to DWI images to define the infarct core using a pixel-based receiver operating characteristic curve analysis to calculate the area under the curve (AUC) for thresholds from PCT maps that were co-registered with the DWI slice location. RESULTS: A relative cerebral blood flow (CBF) of 45% of the contralateral hemisphere was found to be the most accurate threshold for describing the infarct core (AUC 0.788), and it was also by far the most frequent threshold with the highest AUC across patients. CONCLUSION: CBF thresholds on PCT define the acute infarct core more accurately than do other PCT thresholds, including a cerebral blood volume of 2 ml/100 g.
Keywords
Neurology and Neuromuscular Diseases; Nervous System and DisordersExport Reference in RIS Format
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