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dc.contributor.authorBivard, A
dc.contributor.authorMcElduff, P
dc.contributor.authorSpratt, N
dc.contributor.authorLevi, C
dc.contributor.authorParsons, M
dc.identifierpii: 000321897
dc.identifier.citationBivard, A., McElduff, P., Spratt, N., Levi, C. & Parsons, M. (2011). Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography. CEREBROVASCULAR DISEASES, 31 (3), pp.238-245.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractBACKGROUND: Perfusion computed tomography (PCT) shows promise in acute stroke assessment. However, the accuracy of CT perfusion thresholds in defining the acute infarct core remains uncertain. METHOD: Concurrent PCT and MRI-DWI performed 3-6 h after symptoms onset were assessed in 57 ischemic stroke patients. PCT was compared to DWI images to define the infarct core using a pixel-based receiver operating characteristic curve analysis to calculate the area under the curve (AUC) for thresholds from PCT maps that were co-registered with the DWI slice location. RESULTS: A relative cerebral blood flow (CBF) of 45% of the contralateral hemisphere was found to be the most accurate threshold for describing the infarct core (AUC 0.788), and it was also by far the most frequent threshold with the highest AUC across patients. CONCLUSION: CBF thresholds on PCT define the acute infarct core more accurately than do other PCT thresholds, including a cerebral blood volume of 2 ml/100 g.
dc.subjectNeurology and Neuromuscular Diseases; Nervous System and Disorders
dc.titleDefining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.source.titleCEREBROVASCULAR DISEASES
melbourne.contributor.authorBivard, Andrew
melbourne.fieldofresearch320905 Neurology and neuromuscular diseases
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

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