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    Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder

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    Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder (119.6Kb)

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    Author
    Dileo, JF; Brewer, WJ; Hopwood, M; Anderson, V; Creamer, M
    Date
    2008-04-01
    Source Title
    PSYCHOLOGICAL MEDICINE
    Publisher
    CAMBRIDGE UNIV PRESS
    University of Melbourne Author/s
    Brewer, Warrick; Hopwood, Malcolm; Creamer, Mark; DILEO, JOHN
    Affiliation
    Department of Psychology
    ORYGEN Research Centre
    Department of Psychiatry
    Veterans Psychiatry Unit, Austin Health
    Australian Centre for Posttraumatic Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Dileo, J. F., Brewer, W. J., Hopwood, M., Anderson, V. & Creamer, M. (2008). Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder. PSYCHOLOGICAL MEDICINE, 38 (4), pp.523-531. https://doi.org/10.1017/S0033291707001456.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/33011
    DOI
    10.1017/S0033291707001456
    Description

    © 2007 Cambridge University Press. Online edition of the journal is available at http://journals.cambridge.org/PSM

    Abstract
    BACKGROUND: Due to neuropsychological conceptualizations of orbitoprefrontal cortex (OFC) dysfunction underpinning impulsive aggression and the incidence of such behaviour in post-traumatic stress disorder (PTSD), this study aimed to explore olfactory identification (OI) ability in war veterans with PTSD as a probe of putative OFC dysfunction; and to explore the utility of OI ability in predicting aggressive and impulsive behavior in this clinical population. METHOD: Participants comprised 31 out-patient male war veterans with PTSD (mean=58.23 years, s.d.=2.56) recruited from a Melbourne Veterans Psychiatry Unit, and 31 healthy age- and gender-matched controls (mean=56.84 years, s.d.=7.24). All participants were assessed on clinical measures of PTSD, depression, anxiety, and alcohol misuse; olfactory identification; neurocognitive measures of dorsolateral prefrontal, lateral prefrontal and mesial temporal functioning; and self-report measures of aggression and impulsivity. RESULTS: War veterans with PTSD exhibited significant OI deficits (OIDs) compared to controls, despite uncompromised performance on cognitive measures. OIDs remained after covaring for IQ, anxiety, depression and alcohol misuse, and were significant predictors of aggression and impulsivity. CONCLUSIONS: This research contributes to emerging evidence of orbitoprefrontal dysfunction in the pathophysiology underlying PTSD. This is the first study to report OIDs as a predictor of aggression and impulsivity in this clinical population. It prompts further exploration of the potential diagnostic utility of OIDs in the assessment of PTSD. Such measures may help delineate the clinical complexity of PTSD, and support more targeted interventions for individuals with a greater susceptibility to aggressive and impulsive behaviors.
    Keywords
    aggression; impulsivity; olfactory identification; post-traumatic stress disorder

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