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dc.contributor.authorDileo, JF
dc.contributor.authorBrewer, WJ
dc.contributor.authorHopwood, M
dc.contributor.authorAnderson, V
dc.contributor.authorCreamer, M
dc.date.available2014-05-22T07:44:41Z
dc.date.issued2008-04-01
dc.identifierpii: S0033291707001456
dc.identifier.citationDileo, J. F., Brewer, W. J., Hopwood, M., Anderson, V. & Creamer, M. (2008). Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder. PSYCHOLOGICAL MEDICINE, 38 (4), pp.523-531. https://doi.org/10.1017/S0033291707001456.
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/11343/33011
dc.description© 2007 Cambridge University Press. Online edition of the journal is available at http://journals.cambridge.org/PSM
dc.description.abstractBACKGROUND: Due to neuropsychological conceptualizations of orbitoprefrontal cortex (OFC) dysfunction underpinning impulsive aggression and the incidence of such behaviour in post-traumatic stress disorder (PTSD), this study aimed to explore olfactory identification (OI) ability in war veterans with PTSD as a probe of putative OFC dysfunction; and to explore the utility of OI ability in predicting aggressive and impulsive behavior in this clinical population. METHOD: Participants comprised 31 out-patient male war veterans with PTSD (mean=58.23 years, s.d.=2.56) recruited from a Melbourne Veterans Psychiatry Unit, and 31 healthy age- and gender-matched controls (mean=56.84 years, s.d.=7.24). All participants were assessed on clinical measures of PTSD, depression, anxiety, and alcohol misuse; olfactory identification; neurocognitive measures of dorsolateral prefrontal, lateral prefrontal and mesial temporal functioning; and self-report measures of aggression and impulsivity. RESULTS: War veterans with PTSD exhibited significant OI deficits (OIDs) compared to controls, despite uncompromised performance on cognitive measures. OIDs remained after covaring for IQ, anxiety, depression and alcohol misuse, and were significant predictors of aggression and impulsivity. CONCLUSIONS: This research contributes to emerging evidence of orbitoprefrontal dysfunction in the pathophysiology underlying PTSD. This is the first study to report OIDs as a predictor of aggression and impulsivity in this clinical population. It prompts further exploration of the potential diagnostic utility of OIDs in the assessment of PTSD. Such measures may help delineate the clinical complexity of PTSD, and support more targeted interventions for individuals with a greater susceptibility to aggressive and impulsive behaviors.
dc.languageEnglish
dc.publisherCAMBRIDGE UNIV PRESS
dc.subjectaggression
dc.subjectimpulsivity
dc.subjectolfactory identification
dc.subjectpost-traumatic stress disorder
dc.titleOlfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder
dc.typeJournal Article
dc.identifier.doi10.1017/S0033291707001456
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliationMurdoch Children’s Research Institute
melbourne.affiliation.departmentDepartment of Psychology
melbourne.affiliation.departmentORYGEN Research Centre
melbourne.affiliation.departmentDepartment of Psychiatry
melbourne.affiliation.departmentVeterans Psychiatry Unit, Austin Health
melbourne.affiliation.departmentAustralian Centre for Posttraumatic Mental Health
melbourne.publication.statusPublished
melbourne.source.titlePSYCHOLOGICAL MEDICINE
melbourne.source.volume38
melbourne.source.issue4
melbourne.source.pages523-531
melbourne.publicationid103981
dc.description.doi10.1017/S0033291707001456
melbourne.elementsid302321
melbourne.contributor.authorBrewer, Warrick
melbourne.contributor.authorHopwood, Malcolm
melbourne.contributor.authorCreamer, Mark
melbourne.contributor.authorDILEO, JOHN
dc.identifier.eissn1469-8978
melbourne.accessrightsOpen Access


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