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dc.contributor.authorvan Drongelen, J
dc.contributor.authorvan Koppen, A
dc.contributor.authorPertijs, J
dc.contributor.authorGooi, JH
dc.contributor.authorParry, LJ
dc.contributor.authorSweep, FCGJ
dc.contributor.authorLotgering, FK
dc.contributor.authorSmits, P
dc.contributor.authorSpaanderman, MEA
dc.date.available2014-05-22T07:49:52Z
dc.date.issued2012-03-01
dc.identifierpii: japplphysiol.00470.2011
dc.identifier.citationvan Drongelen, J., van Koppen, A., Pertijs, J., Gooi, J. H., Parry, L. J., Sweep, F. C. G. J., Lotgering, F. K., Smits, P. & Spaanderman, M. E. A. (2012). Impaired vascular responses to relaxin in diet-induced overweight female rats. JOURNAL OF APPLIED PHYSIOLOGY, 112 (6), pp.962-969. https://doi.org/10.1152/japplphysiol.00470.2011.
dc.identifier.issn8750-7587
dc.identifier.urihttp://hdl.handle.net/11343/33040
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractRelaxin mediates renal and mesenteric vascular adaptations to pregnancy by increasing endothelium-dependent vasodilation and compliance and decreasing myogenic reactivity. Diet-induced overweight and obesity are associated with impaired endothelial dysfunction and vascular remodeling leading to a reduction in arterial diameter. In this study, we tested the hypothesis that local vascular responses to relaxin are impaired in diet-induced overweight female rats on a high-fat cafeteria-style diet for 9 wk. Rats were chronically infused with either relaxin or placebo for 5 days, and vascular responses were measured in isolated mesenteric arteries and the perfused kidney. Diet-induced overweight significantly increased sensitivity to phenylephrine (by 17%) and vessel wall thickness, and reduced renal perfusion flow (RPFF; by 16%), but did not affect flow-mediated vasodilation, myogenic reactivity, and vascular compliance. In the normal weight rats, relaxin treatment significantly enhanced flow-mediated vasodilation (2.67-fold), decreased myogenic reactivity, and reduced sensitivity to phenylephrine (by 28%), but had no effect on compliance or RPFF. NO blockade by l-NAME diminished most relaxin-mediated effects. In diet-induced overweight rats, the vasodilator effects of relaxin were markedly reduced for flow-mediated vasodilation, sensitivity to phenylephrine, and myogenic response compared with the normal diet rats, mostly persistent under l-NAME. Our data demonstrate that some of the vasodilator responses to in vivo relaxin administration are impaired in isolated mesenteric arteries and the perfused kidney in diet-induced overweight female rats. This does not result from a decrease in Rxfp1 (relaxin family peptide receptor) expression but is likely to result from downstream disruption to endothelial-dependent mechanisms in diet-induced overweight animals.
dc.languageEnglish
dc.publisherAMER PHYSIOLOGICAL SOC
dc.subjectReproduction; Systems Physiology; Expanding Knowledge in the Medical and Health Sciences; Reproductive System and Disorders
dc.titleImpaired vascular responses to relaxin in diet-induced overweight female rats
dc.typeJournal Article
dc.identifier.doi10.1152/japplphysiol.00470.2011
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentZoology
melbourne.source.titleJournal of Applied Physiology
melbourne.source.volume112
melbourne.source.issue6
melbourne.source.pages962-969
melbourne.publicationid189628
melbourne.elementsid421908
melbourne.contributor.authorParry, Laura
melbourne.contributor.authorGooi, Jonathan
dc.identifier.eissn1522-1601
melbourne.fieldofresearch321503 Reproduction
melbourne.fieldofresearch320803 Systems physiology
melbourne.seocode280103 Expanding knowledge in the biomedical and clinical science
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository


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