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dc.contributor.authorTeh, AW
dc.contributor.authorKistler, PM
dc.contributor.authorLee, G
dc.contributor.authorMedi, C
dc.contributor.authorHeck, PM
dc.contributor.authorSpence, SJ
dc.contributor.authorSparks, PB
dc.contributor.authorMorton, JB
dc.contributor.authorKalman, JM
dc.identifier.citationTeh, A. W., Kistler, P. M., Lee, G., Medi, C., Heck, P. M., Spence, S. J., Sparks, P. B., Morton, J. B. & Kalman, J. M. (2012). Electroanatomic Remodeling of the Left Atrium in Paroxysmal and Persistent Atrial Fibrillation Patients Without Structural Heart Disease. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 23 (3), pp.232-238.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractINTRODUCTION: The nature of the atrial substrate thought to contribute toward maintaining atrial fibrillation (AF) outside the pulmonary veins remains poorly defined. Therefore, our objective was to determine whether patients with paroxysmal and persistent AF have an abnormal electroanatomic substrate within the left atrium (LA). METHODS AND RESULTS: Thirty-one patients with AF (17 paroxysmal AF and 14 persistent AF) were compared with 15 age-matched controls with left-sided supraventricular tachycardia (SVT). High-density 3-dimensional electroanatomic maps were created and the LA was divided into 8 segments for regional analysis. Bipolar voltage, conduction, and effective refractory periods (ERPs) of the posterior LA, left atrial appendage (LAA), and distal coronary sinus (CSd) and percentage complex signals were assessed. In the majority of LA regions, compared with controls, AF patients had: (1) lower mean voltage and a higher percentage low voltage; (2) slower conduction; and (3) more prevalent complex signals. Many of these changes were more marked in the persistent than the paroxysmal AF group. CONCLUSIONS: Patients with AF have lower regional voltage, increased proportion of low voltage, slowed conduction, and increased proportion of complex signals compared to controls. Many of these changes are more pronounced in persistent AF patients, suggesting there may be a progressive nature to the changes. Differences occurred in the absence of structural heart disease. These substrate abnormalities provide further insight into the progressive nature of atrial remodeling and the mechanisms involved in maintenance of AF.
dc.subjectCardiology (incl. Cardiovascular Diseases); Cardiovascular System and Diseases
dc.titleElectroanatomic Remodeling of the Left Atrium in Paroxysmal and Persistent Atrial Fibrillation Patients Without Structural Heart Disease
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.contributor.authorKistler, Peter
melbourne.contributor.authorSparks, Paul
melbourne.contributor.authorMorton, Joseph
melbourne.contributor.authorKalman, Jonathan
melbourne.contributor.authorTEH, ANDREW
melbourne.contributor.authorMEDI, CAROLINE
melbourne.contributor.authorHECK, PATRICK
melbourne.contributor.authorLee, Geoffrey
melbourne.fieldofresearch320101 Cardiology (incl. cardiovascular diseases)
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

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