Intracellular competition for fates in the immune system
AuthorDuffy, KR; Hodgkin, PD
Source TitleTrends in Cell Biology
PublisherELSEVIER SCIENCE LONDON
University of Melbourne Author/sHodgkin, Philip
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsDuffy, K. R. & Hodgkin, P. D. (2012). Intracellular competition for fates in the immune system. TRENDS IN CELL BIOLOGY, 22 (9), pp.457-464. https://doi.org/10.1016/j.tcb.2012.05.004.
Access StatusThis item is currently not available from this repository
C5 - Other Refereed Contribution to Refereed Journals
During an adaptive immune response, lymphocytes proliferate for five to 20 generations, differentiating to take on effector functions, before cessation and cell death become dominant. Recent experimental methodologies enable direct observation of individual lymphocytes and the times at which they adopt fates. Data from these experiments reveal diversity in fate selection, heterogeneity and involved correlation structures in times to fate, as well as considerable familial correlations. Despite the significant complexity, these data are consistent with the simple hypothesis that each cell possesses autonomous processes, subject to temporal competition, leading to each fate. This article addresses the evidence for this hypothesis, its hallmarks, and, should it be an appropriate description of a cell system, its ramifications for manipulation.
KeywordsAutoimmunity; Cellular Immunology; Immune System and Allergy
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