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    Novel versus traditional risk markers for diabetic retinopathy

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    Author
    Sasongko, MB; Wong, TY; Nguyen, TT; Shaw, JE; Jenkins, AJ; Wang, JJ
    Date
    2012-03-01
    Source Title
    DIABETOLOGIA
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Wong, Tien; Nguyen, Thanh; Jenkins, Alicia; WANG, JIE; SASONGKO, MUHAMMAD BAYU
    Affiliation
    Ophthalmology Eye And Ear Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Sasongko, M. B., Wong, T. Y., Nguyen, T. T., Shaw, J. E., Jenkins, A. J. & Wang, J. J. (2012). Novel versus traditional risk markers for diabetic retinopathy. DIABETOLOGIA, 55 (3), pp.666-670. https://doi.org/10.1007/s00125-011-2424-x.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33048
    DOI
    10.1007/s00125-011-2424-x
    Description

    C1 - Journal Articles Refereed

    Abstract
    AIMS/HYPOTHESIS: To explore the relative contribution of novel and traditional risk markers for diabetic retinopathy (DR). METHODS: A clinic-based study of 224 diabetic patients (85 type 1, 139 type 2) from a diabetes clinic was performed. DR was graded from fundus photographs according to the Airlie House Classification system and classified as absent or present (at least ETDRS level 14). Novel risk markers assessed included serum apolipoprotein (Apo) AI and B, skin microvascular responses to acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent) iontophoresis, flicker-light-induced retinal vasodilation and retinal vascular tortuosity. Relative contribution was determined by semi-partial correlation coefficient generated from a logistic regression model containing all traditional and novel risk markers simultaneously. RESULTS: There were 144 (64.3%) participants with DR. Of the novel markers, ApoAI, flicker-light-induced vasodilation and retinal arteriolar tortuosity were significantly associated with DR, independently of traditional measures (all p < 0.03). Diabetes duration contributed most (51%) to the risk of DR, followed by ApoAI (16%), systolic blood pressure (13%), retinal arteriolar tortuosity (8%) and flicker-light-induced venular and arteriolar dilation (3% and 0.5%, respectively). CONCLUSIONS/INTERPRETATION: ApoAI and retinal arteriolar tortuosity made considerable contributions to DR risk, independently of traditional risk markers. Findings from this study suggest that serum ApoAI and retinal arteriolar tortuosity may be novel and independent risk markers of DR.
    Keywords
    Ophthalmology; Hearing; Vision; Speech and Their Disorders

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