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dc.contributor.authorBrown, RM
dc.contributor.authorMustafa, S
dc.contributor.authorAyoub, MA
dc.contributor.authorDodd, PR
dc.contributor.authorPfleger, KDG
dc.contributor.authorLawrence, AJ
dc.date.available2014-05-22T07:53:43Z
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.available2012-04-16
dc.date.issued2012-01-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209177700080&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifierUNSP 84
dc.identifier.citationBrown, R. M., Mustafa, S., Ayoub, M. A., Dodd, P. R., Pfleger, K. D. G. & Lawrence, A. J. (2012). mGlu5 receptor functional interactions and addiction. FRONTIERS IN PHARMACOLOGY, 3, https://doi.org/10.3389/fphar.2012.00084.
dc.identifier.issn1663-9812
dc.identifier.urihttp://hdl.handle.net/11343/33061
dc.descriptionC5 - Other Refereed Contribution to Refereed Journals
dc.description.abstractThe idea of "receptor mosaics" is that proteins may form complex and dynamic networks with respect to time and composition. These have the potential to markedly expand the diversity and specificity of G protein-coupled receptors (GPCR) signaling, particularly in neural cells, where a few key receptors have been implicated in many neurological and psychiatric disorders, including addiction. Metabotropic glutamate type 5 receptors (mGlu5) can form complexes with other GPCRs, including adenosine A(2A) and dopamine D(2) receptors. mGlu5-containing complexes have been reported in the striatum, a brain region critical for mediating the rewarding and incentive motivational properties of drugs of abuse. mGlu5-containing complexes and/or downstream interactions between divergent receptors may play roles in addiction-relevant behaviors. Interactions between mGlu5 receptors and other GPCRs can regulate the rewarding and conditioned effects of drugs as well as drug-seeking behaviors. mGlu5 complexes may influence striatal function, including GABAergic output of striatopallidal neurons and glutamatergic input from corticostriatal afferents. Given their discrete localization, mGlu5-[non-mGlu5] receptor interactions and/or mGlu5-containing complexes may minimize off-target effects and thus provide a novel avenue for drug discovery. The therapeutic targeting of receptor-receptor functional interactions and/or receptor mosaics in a tissue specific or temporal manner (for example, a sub-population of receptors in a "pathological state") might reduce detrimental side effects that may otherwise impair vital brain functions.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.subjectPharmacology and Pharmaceutical Sciences not elsewhere classified; Health not elsewhere classified
dc.titlemGlu5 receptor functional interactions and addiction
dc.typeJournal Article
dc.identifier.doi10.3389/fphar.2012.00084
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentFlorey Department Of Neuroscience And Mental Health
melbourne.source.titleFRONTIERS IN PHARMACOLOGY
melbourne.source.volume3
dc.research.codefor111599
dc.research.codeseo2008929999
dc.rights.licenseCC BY-NC
melbourne.publicationid195687
melbourne.elementsid355602
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345582
melbourne.contributor.authorLawrence, Andrew
melbourne.contributor.authorBrown, Robyn
dc.identifier.eissn1663-9812
melbourne.conference.locationSwitzerland
melbourne.accessrightsAccess this item via the Open Access location


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