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    Drugs of abuse and increased risk of psychosis development

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    Author
    Gururajan, A; Manning, EE; Klug, M; van den Buuse, M
    Date
    2012-12-01
    Source Title
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
    Publisher
    SAGE PUBLICATIONS LTD
    University of Melbourne Author/s
    van den Buuse, Maarten; GURURAJAN, ANAND; Manning, Elizabeth; Klug, Maren
    Affiliation
    Centre For Neuroscience Research
    Metadata
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    Document Type
    Journal Article
    Citations
    Gururajan, A., Manning, E. E., Klug, M. & van den Buuse, M. (2012). Drugs of abuse and increased risk of psychosis development. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 46 (12), pp.1120-1135. https://doi.org/10.1177/0004867412455232.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33063
    DOI
    10.1177/0004867412455232
    NHMRC Grant code
    NHMRC/566879
    Description

    C1 - Journal Articles Refereed

    Abstract
    OBJECTIVE: There is considerable evidence to suggest that the abuse of illicit drugs, particularly cannabis and methamphetamine, has aetiological roles in the pathogenesis of psychosis and schizophrenia. Factors that may increase susceptibility to the propsychotic effects of these drugs include the age at which the abuse starts as well as family history of genetic polymorphisms relevant to the pathophysiology of this disorder. However, the neurobiological mechanisms involved in drug abuse-associated psychosis remain largely unclear. METHODS AND RESULTS: This paper presents an overview of the available evidence, including clinical, animal model, and molecular studies, with a focus on brain regions and neurotransmitters systems, such as dopamine and glutamate, previously implicated in psychosis. CONCLUSION: It is clear that further studies are urgently needed to provide a greater insight into the mechanisms that mediate the long-term and neurodevelopmental effects of cannabis and methamphetamine. A dialogue between basic science and clinical research may help to identify at-risk individuals and novel pathways for treatment and prevention.
    Keywords
    Psychiatry (incl. Psychotherapy); Mental Health

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