Drugs of abuse and increased risk of psychosis development
AuthorGururajan, A; Manning, EE; Klug, M; van den Buuse, M
Source TitleAUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
PublisherSAGE PUBLICATIONS LTD
University of Melbourne Author/svan den Buuse, Maarten; GURURAJAN, ANAND; Manning, Elizabeth; Klug, Maren
AffiliationCentre For Neuroscience Research
Document TypeJournal Article
CitationsGururajan, A; Manning, EE; Klug, M; van den Buuse, M, Drugs of abuse and increased risk of psychosis development, AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2012, 46 (12), pp. 1120 - 1135
Access StatusThis item is currently not available from this repository
NHMRC Grant codeNHMRC/566879
C1 - Journal Articles Refereed
OBJECTIVE: There is considerable evidence to suggest that the abuse of illicit drugs, particularly cannabis and methamphetamine, has aetiological roles in the pathogenesis of psychosis and schizophrenia. Factors that may increase susceptibility to the propsychotic effects of these drugs include the age at which the abuse starts as well as family history of genetic polymorphisms relevant to the pathophysiology of this disorder. However, the neurobiological mechanisms involved in drug abuse-associated psychosis remain largely unclear. METHODS AND RESULTS: This paper presents an overview of the available evidence, including clinical, animal model, and molecular studies, with a focus on brain regions and neurotransmitters systems, such as dopamine and glutamate, previously implicated in psychosis. CONCLUSION: It is clear that further studies are urgently needed to provide a greater insight into the mechanisms that mediate the long-term and neurodevelopmental effects of cannabis and methamphetamine. A dialogue between basic science and clinical research may help to identify at-risk individuals and novel pathways for treatment and prevention.
KeywordsPsychiatry (incl. Psychotherapy); Mental Health
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