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dc.contributor.authorChan, W
dc.contributor.authorStub, D
dc.contributor.authorClark, DJ
dc.contributor.authorAjani, AE
dc.contributor.authorAndrianopoulos, N
dc.contributor.authorBrennan, AL
dc.contributor.authorNew, G
dc.contributor.authorBlack, A
dc.contributor.authorShaw, JA
dc.contributor.authorReid, CM
dc.contributor.authorDart, AM
dc.contributor.authorDuffy, SJ
dc.date.available2014-05-22T07:55:43Z
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.available2011-09-30
dc.date.issued2012-02-15
dc.identifierpii: S0002-9149(11)03028-1
dc.identifier.citationChan, W., Stub, D., Clark, D. J., Ajani, A. E., Andrianopoulos, N., Brennan, A. L., New, G., Black, A., Shaw, J. A., Reid, C. M., Dart, A. M. & Duffy, S. J. (2012). Usefulness of Transient and Persistent No Reflow to Predict Adverse Clinical Outcomes Following Percutaneous Coronary Intervention. AMERICAN JOURNAL OF CARDIOLOGY, 109 (4), pp.478-485. https://doi.org/10.1016/j.amjcard.2011.09.037.
dc.identifier.issn0002-9149
dc.identifier.urihttp://hdl.handle.net/11343/33072
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe no reflow phenomenon is reported to occur in >2% of all percutaneous coronary interventions (PCIs) and portends a poor prognosis. We analyzed data from 5,286 consecutive patients who underwent PCI from the Melbourne Interventional Group (MIG) registry from April 2004 through January 2008 who had 30-day follow-up completed. Patients without no reflow (normal reflow, n = 5,031) were compared to 255 (4.8%) with no reflow (n = 217 for transient no reflow, n = 38 for persistent no reflow). Patients with transient or persistent no reflow were more likely to present with ST-elevation myocardial infarction (MI) or cardiogenic shock (p <0.0001 for the 2 comparisons). They were also more likely to have complex lesions (American College of Cardiology/American Heart Association type B2/C), have lesions within a bypass graft, require an intra-aortic balloon pump, receive glycoprotein IIb/IIIa inhibition, and have a longer mean stent length (p <0.0001 for all comparisons). In-hospital outcomes were significantly worse in those patients with transient or persistent no reflow, with increased death, periprocedural MI, renal impairment, and major adverse cardiac events (p <0.0001 for all comparisons). Similarly, transient and persistent no reflow portended worse 30-day clinical outcomes, with a progressive increase in mortality (normal reflow 1.7% vs transient no reflow 5.5% vs persistent no reflow 13.2%, p <0.0001), MI, target vessel revascularization, and major adverse cardiac events (p <0.0001 for all comparisons) compared to patients with normal flow. In conclusion, transient or persistent no reflow complicates approximately 1 in 20 PCIs and results in stepwise increases in in-hospital and 30-day adverse outcomes.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherEXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
dc.subjectCardiology (incl. Cardiovascular Diseases); Cardiovascular System and Diseases
dc.titleUsefulness of Transient and Persistent No Reflow to Predict Adverse Clinical Outcomes Following Percutaneous Coronary Intervention
dc.typeJournal Article
dc.identifier.doi10.1016/j.amjcard.2011.09.037
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentNorth West Academic Centre
melbourne.source.titleAMERICAN JOURNAL OF CARDIOLOGY
melbourne.source.volume109
melbourne.source.issue4
melbourne.source.pages478-485
dc.research.codefor110201
dc.research.codeseo2008920103
melbourne.publicationid186418
melbourne.elementsid426211
melbourne.contributor.authorBarlis, Peter
melbourne.contributor.authorAjani, Andrew
melbourne.contributor.authorClark, David
melbourne.contributor.authorBLACK, ALEXANDER
melbourne.contributor.authorChan, William
dc.identifier.eissn1879-1913
melbourne.conference.locationUnited States
pubs.acceptance.date2011-09-30
melbourne.accessrightsThis item is currently not available from this repository


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