Caenorhabditis elegans Maintains Highly Compartmentalized Cellular Distribution of Metals and Steep Concentration Gradients of Manganese
AuthorMcColl, G; James, SA; Mayo, S; Howard, DL; Ryan, CG; Kirkham, R; Moorhead, GF; Paterson, D; de Jonge, MD; Bush, AI
Source TitlePLOS ONE
PublisherPUBLIC LIBRARY SCIENCE
University of Melbourne Author/sRyan, Christopher; McColl, Gawain; Bush, Ashley; MOORHEAD, GARETH; James, Simon
Document TypeJournal Article
CitationsMcColl, G., James, S. A., Mayo, S., Howard, D. L., Ryan, C. G., Kirkham, R., Moorhead, G. F., Paterson, D., de Jonge, M. D. & Bush, A. I. (2012). Caenorhabditis elegans Maintains Highly Compartmentalized Cellular Distribution of Metals and Steep Concentration Gradients of Manganese. PLOS ONE, 7 (2), https://doi.org/10.1371/journal.pone.0032685.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290589
NHMRC Grant codeNHMRC/1037234
C1 - Journal Articles Refereed
Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these metals. We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis elegans.
KeywordsDevelopmental Genetics (incl. Sex Determination); Health Related to Ageing
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