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dc.contributor.authorIshikawa, K
dc.contributor.authorWan, L
dc.contributor.authorCalzavacca, P
dc.contributor.authorBellomo, R
dc.contributor.authorBailey, M
dc.contributor.authorMay, CN
dc.identifierpii: PONE-D-11-17513
dc.identifier.citationIshikawa, K., Wan, L., Calzavacca, P., Bellomo, R., Bailey, M. & May, C. N. (2012). The Effects of Terlipressin on Regional Hemodynamics and Kidney Function in Experimental Hyperdynamic Sepsis. PLOS ONE, 7 (2),
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractBACKGROUND AND AIMS: Although terlipressin (TP) may improve renal function in cirrhotic patients, its use in sepsis remains controversial due to concerns about regional ischemia. We investigated the effects of TP on regional hemodynamics and kidney function in experimental hyperdynamic sepsis. METHODS: We studied thirteen merino ewes in a university physiology laboratory using a randomized controlled cross over design. We implanted flow probes around the pulmonary, circumflex coronary, superior mesenteric, renal and iliac arteries. We injected live Escherichia coli and induced hyperdynamic sepsis. We treated animals with either bolus vehicle or a single dose of TP (sTP = 1 mg). In a second group, after 1 mg of TP, two additional bolus injections (mTP) of 0.5 mg were given at 2 hourly intervals. MAIN RESULTS: sTP (1 mg) significantly increased mean arterial pressure (MAP) (74 to 89 mmHg; P<0.0001) creatinine clearance (31 to 85 mL/min; P<0.0001) and urine output (24 to 307 mL/hr) (P<0.0001). However, it decreased CO (5.7 to 3.9 L/min; p<0.0001), coronary blood flow (CBF) (43 to 32 mL/min; p<0.0001) and mesenteric blood flow (MBF) (944 to 625 mL/min; p = 0.004) and increased blood lactate (2.1 to 4.0 mmol/L; p<0.0001). Extra doses of TP caused little additional effect. CONCLUSIONS: In hyperdynamic sepsis, bolus TP transiently improves MAP and renal function, but reduces CO, CBF and MBF, and increases blood lactate. Caution should be applied when prescribing bolus TP in septic patients at risk of coronary or mesenteric ischemia.
dc.subjectCardiovascular Medicine and Haematology not elsewhere classified; Expanding Knowledge in the Medical and Health Sciences
dc.titleThe Effects of Terlipressin on Regional Hemodynamics and Kidney Function in Experimental Hyperdynamic Sepsis
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentFlorey Department Of Neuroscience And Mental Health
melbourne.source.titlePLoS One
dc.rights.licenseCC BY
melbourne.contributor.authorMay, Clive
melbourne.contributor.authorBellomo, Rinaldo
melbourne.contributor.authorBailey, Michael
melbourne.fieldofresearch320199 Cardiovascular medicine and haematology not elsewhere classified
melbourne.seocode280103 Expanding knowledge in the biomedical and clinical science
melbourne.accessrightsAccess this item via the Open Access location

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