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    The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

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    Author
    Sena, ES; Jeffreys, AL; Cox, SF; Sastra, SA; Churilov, L; Rewell, S; Batchelor, PE; van der Worp, HB; Macleod, MR; Howells, DW
    Date
    2013-04-01
    Source Title
    INTERNATIONAL JOURNAL OF STROKE
    Publisher
    WILEY-BLACKWELL
    University of Melbourne Author/s
    Batchelor, Peter; Howells, David; JEFFREYS, AMY; Churilov, Leonid; Cox, Susan; Rewell, Sarah; SASTRA, STEPHEN
    Affiliation
    Florey Department Of Neuroscience And Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Sena, E. S., Jeffreys, A. L., Cox, S. F., Sastra, S. A., Churilov, L., Rewell, S., Batchelor, P. E., van der Worp, H. B., Macleod, M. R. & Howells, D. W. (2013). The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine. INTERNATIONAL JOURNAL OF STROKE, 8 (3), pp.180-185. https://doi.org/10.1111/j.1747-4949.2012.00834.x.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33076
    DOI
    10.1111/j.1747-4949.2012.00834.x
    Description

    C1 - Journal Articles Refereed

    Abstract
    BACKGROUND: Hypothermia is a promising experimental treatment for acute ischemic stroke. Human trials are still at an early stage, with the focus now on using hypothermia in awake patients. Pethidine (meperidine) is the principle agent used to control shivering in humans; however, whether it has any modulating effects on the neuroprotective efficacy of hypothermia is unknown. AIM: The aim of this study was to determine if pethidine influences the neuroprotective effect of hypothermia in experimental stroke. METHODS: Seventy-two male spontaneously hypertensive rats were anesthetized with isoflurane and randomly assigned to either normothermia (37. 4 °C rectal temperature); hypothermia (33 °C maintained for 130 mins); normothermia plus pethidine (2.5 mg/kg); or hypothermia plus pethidine. Temporary (90 mins) endovascular occlusion of the middle cerebral artery was induced blinded to treatment allocation and was confirmed with laser Doppler flowmetry. Pethidine and cooling were started immediately after vessel occlusion. Animals in the normothermia group had active temperature management using a heat lamp and fan. Assessments of outcome were carried out 24 after the induction of injury. RESULTS: Thirteen animals met our prespecified criteria for exclusion, and data for 59 rats were presented here. Hypothermia was associated with a 63% reduction in infarct size, and pethidine had no significant impact on the efficacy of hypothermia. No effects were observed in neurobehavioral outcome or edema volume across experimental groups. CONCLUSIONS: The effects of hypothermia in a model of focal ischemia are not affected by administration of pethidine.
    Keywords
    Cardiology (incl. Cardiovascular Diseases); Central Nervous System; Expanding Knowledge in the Medical and Health Sciences

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