The roles of purinergic signaling during gastrointestinal inflammation
Author
Roberts, JA; Lukewich, MK; Sharkey, KA; Furness, JB; Mawe, GM; Lomax, AEDate
2012-12-01Source Title
CURRENT OPINION IN PHARMACOLOGYPublisher
ELSEVIER SCI LTDUniversity of Melbourne Author/s
Furness, JohnAffiliation
Anatomy And NeuroscienceMetadata
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Journal ArticleCitations
Roberts, J. A., Lukewich, M. K., Sharkey, K. A., Furness, J. B., Mawe, G. M. & Lomax, A. E. (2012). The roles of purinergic signaling during gastrointestinal inflammation. CURRENT OPINION IN PHARMACOLOGY, 12 (6), pp.659-666. https://doi.org/10.1016/j.coph.2012.09.011.Access Status
Access this item via the Open Access locationOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515696Description
C1 - Journal Articles Refereed
Abstract
Extracellular purines play important roles as neurotransmitters and paracrine mediators in the gastrointestinal (GI) tract. Inflammation of the GI tract causes marked changes in the release and extracellular catabolism of purines, and can modulate purinoceptor expression and/or signaling. The functional consequences of this include suppression of the purinergic component of inhibitory neuromuscular and neurovascular transmission, increased release of purines from immune and epithelial cells, loss of enteric neurons to damage through P2X(7) purinoceptors, and enhanced activation of pain fibres. The purinergic system represents an important target for drug therapies that may improve GI inflammation and its consequences.
Keywords
Autonomic Nervous System; Nervous System and DisordersExport Reference in RIS Format
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