The roles of purinergic signaling during gastrointestinal inflammation
AuthorRoberts, JA; Lukewich, MK; Sharkey, KA; Furness, JB; Mawe, GM; Lomax, AE
Source TitleCurrent Opinion in Pharmacology
PublisherELSEVIER SCI LTD
University of Melbourne Author/sFurness, John
AffiliationAnatomy And Neuroscience
Document TypeJournal Article
CitationsRoberts, J. A., Lukewich, M. K., Sharkey, K. A., Furness, J. B., Mawe, G. M. & Lomax, A. E. (2012). The roles of purinergic signaling during gastrointestinal inflammation. CURRENT OPINION IN PHARMACOLOGY, 12 (6), pp.659-666. https://doi.org/10.1016/j.coph.2012.09.011.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515696
C1 - Journal Articles Refereed
Extracellular purines play important roles as neurotransmitters and paracrine mediators in the gastrointestinal (GI) tract. Inflammation of the GI tract causes marked changes in the release and extracellular catabolism of purines, and can modulate purinoceptor expression and/or signaling. The functional consequences of this include suppression of the purinergic component of inhibitory neuromuscular and neurovascular transmission, increased release of purines from immune and epithelial cells, loss of enteric neurons to damage through P2X(7) purinoceptors, and enhanced activation of pain fibres. The purinergic system represents an important target for drug therapies that may improve GI inflammation and its consequences.
KeywordsAutonomic Nervous System; Nervous System and Disorders
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