The roles of purinergic signaling during gastrointestinal inflammation

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    Author
    Roberts, JA; Lukewich, MK; Sharkey, KA; Furness, JB; Mawe, GM; Lomax, AE
    Date
    2012-12-01
    Source Title
    Current Opinion in Pharmacology
    Publisher
    ELSEVIER SCI LTD
    University of Melbourne Author/s
    Furness, John
    Affiliation
    Anatomy And Neuroscience
    Metadata
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    Document Type
    Journal Article
    Citations
    Roberts, J. A., Lukewich, M. K., Sharkey, K. A., Furness, J. B., Mawe, G. M. & Lomax, A. E. (2012). The roles of purinergic signaling during gastrointestinal inflammation. CURRENT OPINION IN PHARMACOLOGY, 12 (6), pp.659-666. https://doi.org/10.1016/j.coph.2012.09.011.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/33102
    DOI
    10.1016/j.coph.2012.09.011
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515696
    Description

    C1 - Journal Articles Refereed
    Abstract
    Extracellular purines play important roles as neurotransmitters and paracrine mediators in the gastrointestinal (GI) tract. Inflammation of the GI tract causes marked changes in the release and extracellular catabolism of purines, and can modulate purinoceptor expression and/or signaling. The functional consequences of this include suppression of the purinergic component of inhibitory neuromuscular and neurovascular transmission, increased release of purines from immune and epithelial cells, loss of enteric neurons to damage through P2X(7) purinoceptors, and enhanced activation of pain fibres. The purinergic system represents an important target for drug therapies that may improve GI inflammation and its consequences.
    Keywords
    Autonomic Nervous System; Nervous System and Disorders

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