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dc.contributor.authorRoberts, JA
dc.contributor.authorLukewich, MK
dc.contributor.authorSharkey, KA
dc.contributor.authorFurness, JB
dc.contributor.authorMawe, GM
dc.contributor.authorLomax, AE
dc.date.available2014-05-22T08:01:09Z
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.available2012-09-19
dc.date.issued2012-12-01
dc.identifierpii: S1471-4892(12)00180-4
dc.identifier.citationRoberts, J. A., Lukewich, M. K., Sharkey, K. A., Furness, J. B., Mawe, G. M. & Lomax, A. E. (2012). The roles of purinergic signaling during gastrointestinal inflammation. CURRENT OPINION IN PHARMACOLOGY, 12 (6), pp.659-666. https://doi.org/10.1016/j.coph.2012.09.011.
dc.identifier.issn1471-4892
dc.identifier.urihttp://hdl.handle.net/11343/33102
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractExtracellular purines play important roles as neurotransmitters and paracrine mediators in the gastrointestinal (GI) tract. Inflammation of the GI tract causes marked changes in the release and extracellular catabolism of purines, and can modulate purinoceptor expression and/or signaling. The functional consequences of this include suppression of the purinergic component of inhibitory neuromuscular and neurovascular transmission, increased release of purines from immune and epithelial cells, loss of enteric neurons to damage through P2X(7) purinoceptors, and enhanced activation of pain fibres. The purinergic system represents an important target for drug therapies that may improve GI inflammation and its consequences.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherELSEVIER SCI LTD
dc.subjectAutonomic Nervous System; Nervous System and Disorders
dc.titleThe roles of purinergic signaling during gastrointestinal inflammation
dc.typeJournal Article
dc.identifier.doi10.1016/j.coph.2012.09.011
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentAnatomy And Neuroscience
melbourne.source.titleCURRENT OPINION IN PHARMACOLOGY
melbourne.source.volume12
melbourne.source.issue6
melbourne.source.pages659-666
melbourne.publicationid195756
melbourne.elementsid446226
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515696
melbourne.contributor.authorFurness, John
dc.identifier.eissn1471-4973
melbourne.fieldofresearch320901 Autonomic nervous system
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsAccess this item via the Open Access location


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