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    Systematic Review of the Effectiveness of Pharmacologic Interventions to Improve Quality of Life and Well-being in People With Dementia

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    36
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    Author
    Cooper, C; Mukadam, N; Katona, C; Lyketsos, CG; Blazer, D; Ames, D; Rabins, P; Brodaty, H; Lima, CDM; Livingston, G
    Date
    2013-02-01
    Source Title
    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Ames, David
    Affiliation
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Cooper, C., Mukadam, N., Katona, C., Lyketsos, C. G., Blazer, D., Ames, D., Rabins, P., Brodaty, H., Lima, C. D. M. & Livingston, G. (2013). Systematic Review of the Effectiveness of Pharmacologic Interventions to Improve Quality of Life and Well-being in People With Dementia. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 21 (2), pp.173-183. https://doi.org/10.1016/j.jagp.2012.10.018.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33120
    DOI
    10.1016/j.jagp.2012.10.018
    Description

    C1 - Journal Articles Refereed

    Abstract
    OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewed the 15 randomized controlled trials and one review that fitted predetermined criteria. We included studies that reported the outcomes quality of life, well-being, happiness, or pleasure. MEASUREMENTS: We rated the validity of studies using a checklist. We calculated mean differences between intervention and control groups at follow-up. RESULTS: None of the evaluated trials reported a significant benefit to quality of life or well-being for people with dementia when comparing those taking a drug or its comparator at follow-up (pooled weighted mean difference: 0.18 [95% confidence interval: -0.82 to 0.46]). CONCLUSION: We found no consistent evidence that any drug improves quality of life in people with dementia. We recommend that all dementia trials should include quality of life as an outcome, as this is important to patients, and cannot be presumed from improvements in cognition or other symptomatic outcomes, especially if the latter are small.
    Keywords
    Biological Psychology (Neuropsychology; Psychopharmacology; Physiological Psychology); Psychiatry (incl. Psychotherapy); Mental Health; Health Related to Ageing

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