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    Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

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    Author
    Reyes, S; Fu, Y; Double, KL; Cottam, V; Thompson, LH; Kirik, D; Paxinos, G; Watson, C; Cooper, HM; Halliday, GM
    Date
    2013-03-01
    Source Title
    NEUROBIOLOGY OF AGING
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Thompson, Lachlan
    Affiliation
    Florey Department Of Neuroscience And Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Reyes, S., Fu, Y., Double, K. L., Cottam, V., Thompson, L. H., Kirik, D., Paxinos, G., Watson, C., Cooper, H. M. & Halliday, G. M. (2013). Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. NEUROBIOLOGY OF AGING, 34 (3), pp.873-886. https://doi.org/10.1016/j.neurobiolaging.2012.07.019.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33130
    DOI
    10.1016/j.neurobiolaging.2012.07.019
    NHMRC Grant code
    NHMRC/628542
    NHMRC/1022637
    Description

    C1 - Journal Articles Refereed

    Abstract
    Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the transcription factors pituitary homeobox 3 (Pitx3) and orthodenticle homeobox 2 (Otx2) and the trophic factor receptor deleted in colorectal cancer (DCC), but there is limited information on their expression and localization in adult humans. Pitx3, Otx2, and DCC were immunohistochemically localized in the upper brainstem of adult humans and mice and protein expression assessed using relative intensity measures and online microarray data. Pitx3 was present and highly expressed in most dopamine neurons. Surprisingly, in our elderly subjects no Otx2 immunoreactivity was detected in dopamine neurons, although Otx2 gene expression was found in younger cases. Enhanced DCC gene expression occurred in the substantia nigra, and higher amounts of DCC protein characterized vulnerable ventral nigral dopamine neurons. Our data show that, at the age when Parkinson's disease typically occurs, there are no significant differences in the expression of transcription factors in brainstem dopamine neurons, but those most vulnerable to Parkinson's disease rely more on the trophic factor receptor DCC than other brainstem dopamine neurons.
    Keywords
    Neurology and Neuromuscular Diseases; Neurosciences not elsewhere classified; Expanding Knowledge in the Medical and Health Sciences; Neurodegenerative Disorders Related to Ageing

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