Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
AuthorReyes, S; Fu, Y; Double, KL; Cottam, V; Thompson, LH; Kirik, D; Paxinos, G; Watson, C; Cooper, HM; Halliday, GM
Source TitleNeurobiology of Aging
PublisherELSEVIER SCIENCE INC
University of Melbourne Author/sThompson, Lachlan
AffiliationFlorey Department Of Neuroscience And Mental Health
Document TypeJournal Article
CitationsReyes, S., Fu, Y., Double, K. L., Cottam, V., Thompson, L. H., Kirik, D., Paxinos, G., Watson, C., Cooper, H. M. & Halliday, G. M. (2013). Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. NEUROBIOLOGY OF AGING, 34 (3), pp.873-886. https://doi.org/10.1016/j.neurobiolaging.2012.07.019.
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C1 - Journal Articles Refereed
Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the transcription factors pituitary homeobox 3 (Pitx3) and orthodenticle homeobox 2 (Otx2) and the trophic factor receptor deleted in colorectal cancer (DCC), but there is limited information on their expression and localization in adult humans. Pitx3, Otx2, and DCC were immunohistochemically localized in the upper brainstem of adult humans and mice and protein expression assessed using relative intensity measures and online microarray data. Pitx3 was present and highly expressed in most dopamine neurons. Surprisingly, in our elderly subjects no Otx2 immunoreactivity was detected in dopamine neurons, although Otx2 gene expression was found in younger cases. Enhanced DCC gene expression occurred in the substantia nigra, and higher amounts of DCC protein characterized vulnerable ventral nigral dopamine neurons. Our data show that, at the age when Parkinson's disease typically occurs, there are no significant differences in the expression of transcription factors in brainstem dopamine neurons, but those most vulnerable to Parkinson's disease rely more on the trophic factor receptor DCC than other brainstem dopamine neurons.
KeywordsNeurology and Neuromuscular Diseases; Neurosciences not elsewhere classified; Expanding Knowledge in the Medical and Health Sciences; Neurodegenerative Disorders Related to Ageing
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