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    Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

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    Author
    Dezsi, G; Ozturk, E; Stanic, D; Powell, KL; Blumenfeld, H; O'Brien, TJ; Jones, NC
    Date
    2013-04-01
    Source Title
    EPILEPSIA
    Publisher
    WILEY
    University of Melbourne Author/s
    Dezsi, Gabriella; Powell, Kim; Stanic, Davor; O'Brien, Terence; Jones, Nigel; Ozturk, Ezgi
    Affiliation
    Medicine - Royal Melbourne Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Dezsi, G., Ozturk, E., Stanic, D., Powell, K. L., Blumenfeld, H., O'Brien, T. J. & Jones, N. C. (2013). Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy. EPILEPSIA, 54 (4), pp.635-643. https://doi.org/10.1111/epi.12118.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/33162
    DOI
    10.1111/epi.12118
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618492
    Description

    C1 - Journal Articles Refereed

    Abstract
    PURPOSE: Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has been reported to have disease-modifying antiepileptogenic activity in the WAG/Rij rat model of genetic generalized epilepsy (GGE) with absence seizures. Here we examined whether chronic treatment with ESX (1) possesses antiepileptogenic effects in the genetic absence epilepsy rats from Strasbourg (GAERS) model of GGE, (2) is associated with a mitigation of behavioral comorbidities, and (3) influences gene expression in the somatosensory cortex region where seizures are thought to originate. METHODS: GAERS and nonepileptic control (NEC) rats were chronically treated with ESX (in drinking water) or control (tap water) from 3 to 22 weeks of age. Subsequently, all animals received tap water only for another 12 weeks to assess enduring effects of treatment. Seizure frequency and anxiety-like behaviors were serially assessed throughout the experimental paradigm. Treatment effects on the expression of key components of the epigenetic molecular machinery, the DNA methyltransferase enzymes, were assessed using quantitative polymerase chain reaction (qPCR). KEY FINDINGS: ESX treatment significantly reduced seizures in GAERS during the treatment phase, and this effect was maintained during the 12-week posttreatment phase (p < 0.05). Furthermore, the anxiety-like behaviors present in GAERS were reduced by ESX treatment (p < 0.05). Molecular analysis revealed that ESX treatment was associated with increased expression of DNA methyltransferase enzyme messenger RNA (mRNA) in cortex. SIGNIFICANCE: Chronic ESX treatment has disease-modifying effects in the GAERS model of GGE, with antiepileptogenic effects against absence seizures and mitigation of behavioral comorbidities. The cellular mechanism for these effects may involve epigenetic modifications.
    Keywords
    Central Nervous System; Nervous System and Disorders

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