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dc.contributor.authorSenn, N
dc.contributor.authorRarau, P
dc.contributor.authorManong, D
dc.contributor.authorSalib, M
dc.contributor.authorSiba, P
dc.contributor.authorReeder, JC
dc.contributor.authorRogerson, SJ
dc.contributor.authorGenton, B
dc.contributor.authorMueller, I
dc.date.available2014-05-22T08:15:58Z
dc.date.issued2013-05-15
dc.identifierpii: cit068
dc.identifier.citationSenn, N., Rarau, P., Manong, D., Salib, M., Siba, P., Reeder, J. C., Rogerson, S. J., Genton, B. & Mueller, I. (2013). Effectiveness of Artemether/Lumefantrine for the Treatment of Uncomplicated Plasmodium vivax and P. falciparum Malaria in Young Children in Papua New Guinea. CLINICAL INFECTIOUS DISEASES, 56 (10), pp.1413-1420. https://doi.org/10.1093/cid/cit068.
dc.identifier.issn1058-4838
dc.identifier.urihttp://hdl.handle.net/11343/33181
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractBACKGROUND: Artemisinin combination therapy is recommended as treatment for uncomplicated Plasmodium falciparum (Pf) malaria, whereas chloroquine is still widely used for non-Pf infections. A common treatment for both vivax and falciparum malaria would be welcome. METHODS: A longitudinal prospective effectiveness study of 1682 children aged 3-27 months in outpatient clinics in Papua New Guinea. The main outcome was clinical treatment failure rate following treatment with artemether/lumefantrine (AL). RESULTS: Among 5670 febrile episodes, 1682 (28%) had positive rapid diagnostic test (RDT) results and were treated with AL. A total of 1261 (22%) had an infection confirmed by blood slide examination. Of these, 594 Pv and 332 Pf clinical malaria cases were included in the primary effectiveness analysis. Clinical treatment failure rates at 7, 28, and 42 days were 0.2%, 2.2%, and 12.0%, respectively, for Pv and 0.3%, 1.2%, and 3.6%, respectively, for Pf. A single malaria-unrelated death occurred within 42 days following treatment with AL, in a child who was aparasitemic by blood slide at reattendance. CONCLUSIONS: AL provides a rapid clinical response against both Pf and Pv malaria, but is associated with a high rate of Pv recurrent clinical episodes between days 28 and 42. In order to prevent relapsing infections from long-lasting hypnozoites, AL should ideally be complemented with a course of primaquine. In the absence of better treatment and diagnostic options, the use of AL in young children in routine practice is an acceptable, interim option in coendemic areas where Pv is resistant to chloroquine and specific treatment for Pv hypnozoites not feasible.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.subjectMedical Parasitology; Infectious Diseases
dc.titleEffectiveness of Artemether/Lumefantrine for the Treatment of Uncomplicated Plasmodium vivax and P. falciparum Malaria in Young Children in Papua New Guinea
dc.typeJournal Article
dc.identifier.doi10.1093/cid/cit068
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.source.titleClinical Infectious Diseases
melbourne.source.volume56
melbourne.source.issue10
melbourne.source.pages1413-1420
melbourne.publicationid193013
melbourne.elementsid542053
melbourne.contributor.authorRogerson, Stephen
melbourne.contributor.authorRarau, Patricia
dc.identifier.eissn1537-6591
melbourne.fieldofresearch320704 Medical parasitology
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository


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