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    A model of parity-dependent immunity to placental malaria

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    Author
    Walker, PGT; Griffin, JT; Cairns, M; Rogerson, SJ; van Eijk, AM; ter Kuile, F; Ghani, AC
    Date
    2013-03-01
    Source Title
    NATURE COMMUNICATIONS
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Rogerson, Stephen
    Affiliation
    Medicine - Royal Melbourne Hospital
    Metadata
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    Document Type
    Journal Article
    Citations
    Walker, P. G. T., Griffin, J. T., Cairns, M., Rogerson, S. J., van Eijk, A. M., ter Kuile, F. & Ghani, A. C. (2013). A model of parity-dependent immunity to placental malaria. NATURE COMMUNICATIONS, 4 (1), https://doi.org/10.1038/ncomms2605.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/33186
    DOI
    10.1038/ncomms2605
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615483
    Description

    C1 - Journal Articles Refereed

    Abstract
    Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection.
    Keywords
    Medical Parasitology; Infectious Diseases

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