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dc.contributor.authorWalker, PGT
dc.contributor.authorGriffin, JT
dc.contributor.authorCairns, M
dc.contributor.authorRogerson, SJ
dc.contributor.authorvan Eijk, AM
dc.contributor.authorter Kuile, F
dc.contributor.authorGhani, AC
dc.date.available2014-05-22T08:16:55Z
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.available2013-02-14
dc.date.issued2013-03-01
dc.identifierpii: ncomms2605
dc.identifier.citationWalker, P. G. T., Griffin, J. T., Cairns, M., Rogerson, S. J., van Eijk, A. M., ter Kuile, F. & Ghani, A. C. (2013). A model of parity-dependent immunity to placental malaria. NATURE COMMUNICATIONS, 4 (1), https://doi.org/10.1038/ncomms2605.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/33186
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractPlasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.subjectMedical Parasitology; Infectious Diseases
dc.titleA model of parity-dependent immunity to placental malaria
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms2605
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.source.titleNATURE COMMUNICATIONS
melbourne.source.volume4
melbourne.source.issue1
dc.research.codefor110803
dc.research.codeseo2008920109
dc.rights.licenseCC BY-NC-SA
melbourne.publicationid195331
melbourne.elementsid535708
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615483
melbourne.contributor.authorRogerson, Stephen
dc.identifier.eissn2041-1723
pubs.acceptance.date2013-02-14
melbourne.accessrightsOpen Access


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