Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study
Author
Wirth, A; Gospodarowicz, M; Aleman, BMP; Bressel, M; Ng, A; Chao, M; Hoppe, RT; Thieblemont, C; Tsang, R; Moser, L; ...Date
2013-05-01Source Title
ANNALS OF ONCOLOGYPublisher
OXFORD UNIV PRESSAffiliation
The Sir Peter Maccallum Department Of OncologyMetadata
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Wirth, A., Gospodarowicz, M., Aleman, B. M. P., Bressel, M., Ng, A., Chao, M., Hoppe, R. T., Thieblemont, C., Tsang, R., Moser, L., Specht, L., Szpytma, T., Lennard, A., Seymour, J. F. & Zucca, E. (2013). Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study. ANNALS OF ONCOLOGY, 24 (5), pp.1344-1351. https://doi.org/10.1093/annonc/mds623.Access Status
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C1 - Journal Articles Refereed
Abstract
BACKGROUND: We evaluated the long-term results of radiotherapy for patients with gastric marginal zone lymphoma (GMZL). PATIENTS AND METHODS: We carried out a retrospective, multi-centre study of patients with low-grade GMZL treated by radiotherapy between 17 July 1981 and 25 March 2004. RESULTS: There were 102 eligible patients. Fifty-eight patients were previously untreated and 44 had recurrent/residual disease after prior treatment (HP eradication, chemotherapy and surgery in 35, 9 and 8 patients, respectively, and 7 had >1 prior therapy). Radiation fields included the stomach /involved nodes in 61 patients and whole abdomen in 41. The median radiotherapy dose to stomach was 40 Gy (range 26-46 Gy) in a median 22 fractions. With a median follow-up after radiotherapy of 7.9 years (range 0.3-24 years), 10- and 15-year freedom from treatment failure (FFTF) was 88% (95% CI 82%-95%). Risk factors for TF were a large-cell component (P = 0.036) and an exophytic growth pattern (P = 0.042). Radiotherapy field size, radiotherapy dose, and failure of prior therapy were not associated with inferior FFTF. Ten-year overall survival was 70% (95% CI 60%-82%). CONCLUSIONS: Radiotherapy achieves cure for the majority of patients with low-grade GMZL, including patients who have had prior therapy. Several features may predict a poorer outcome.
Keywords
Radiation Therapy; Cancer and Related DisordersExport Reference in RIS Format
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