Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study
AuthorWirth, A; Gospodarowicz, M; Aleman, BMP; Bressel, M; Ng, A; Chao, M; Hoppe, RT; Thieblemont, C; Tsang, R; Moser, L; ...
Source TitleAnnals of Oncology
PublisherOXFORD UNIV PRESS
AffiliationThe Sir Peter Maccallum Department Of Oncology
Document TypeJournal Article
CitationsWirth, A., Gospodarowicz, M., Aleman, B. M. P., Bressel, M., Ng, A., Chao, M., Hoppe, R. T., Thieblemont, C., Tsang, R., Moser, L., Specht, L., Szpytma, T., Lennard, A., Seymour, J. F. & Zucca, E. (2013). Long-term outcome for gastric marginal zone lymphoma treated with radiotherapy: a retrospective, multi-centre, International Extranodal Lymphoma Study Group study. ANNALS OF ONCOLOGY, 24 (5), pp.1344-1351. https://doi.org/10.1093/annonc/mds623.
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C1 - Journal Articles Refereed
BACKGROUND: We evaluated the long-term results of radiotherapy for patients with gastric marginal zone lymphoma (GMZL). PATIENTS AND METHODS: We carried out a retrospective, multi-centre study of patients with low-grade GMZL treated by radiotherapy between 17 July 1981 and 25 March 2004. RESULTS: There were 102 eligible patients. Fifty-eight patients were previously untreated and 44 had recurrent/residual disease after prior treatment (HP eradication, chemotherapy and surgery in 35, 9 and 8 patients, respectively, and 7 had >1 prior therapy). Radiation fields included the stomach /involved nodes in 61 patients and whole abdomen in 41. The median radiotherapy dose to stomach was 40 Gy (range 26-46 Gy) in a median 22 fractions. With a median follow-up after radiotherapy of 7.9 years (range 0.3-24 years), 10- and 15-year freedom from treatment failure (FFTF) was 88% (95% CI 82%-95%). Risk factors for TF were a large-cell component (P = 0.036) and an exophytic growth pattern (P = 0.042). Radiotherapy field size, radiotherapy dose, and failure of prior therapy were not associated with inferior FFTF. Ten-year overall survival was 70% (95% CI 60%-82%). CONCLUSIONS: Radiotherapy achieves cure for the majority of patients with low-grade GMZL, including patients who have had prior therapy. Several features may predict a poorer outcome.
KeywordsRadiation Therapy; Cancer and Related Disorders
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