Current and emerging antiviral treatments for hepatitis C infection
Author
Doyle, JS; Aspinall, E; Liew, D; Thompson, AJ; Hellard, MEDate
2013-04-01Source Title
BRITISH JOURNAL OF CLINICAL PHARMACOLOGYPublisher
WILEYAffiliation
Medicine - Royal Melbourne HospitalMetadata
Show full item recordDocument Type
Journal ArticleCitations
Doyle, J. S., Aspinall, E., Liew, D., Thompson, A. J. & Hellard, M. E. (2013). Current and emerging antiviral treatments for hepatitis C infection. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75 (4), pp.931-943. https://doi.org/10.1111/j.1365-2125.2012.04419.x.Access Status
Access this item via the Open Access locationOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612710Description
C1 - Journal Articles Refereed
Abstract
Newly licensed direct acting antivirals for hepatitis C virus HCV are able to cure up to 75% of patients chronically infected with genotype-1 infection, which is the predominant HCV strain in Europe and North America. Emerging antiviral therapies promise further increases in virological response, as well as improved tolerability, reduced duration of therapy, and will potentially eliminate the need for interferon use. This review highlights the main therapeutic agents used in current standard of care, including telaprevir and boceprevir. It goes on to evaluate the mechanisms of emerging drugs, their stage of development and response rates seen in research to date. Finally, it projects into the not too distant future to consider treatment strategies involving combinations of agents and interferon-free therapies, and in which patients they might prove most successful.
Keywords
Infectious Diseases; Clinical Pharmacology and Therapeutics; Preventive MedicineExport Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References