Analytical Evaluation of GeneXpert CT/NG, the First Genetic Point-of-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis

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    Author
    Tabrizi, SN; Unemo, M; Golparian, D; Twin, J; Limnios, AE; Lahra, M; Guy, R
    Date
    2013-06-01
    Source Title
    Journal of Clinical Microbiology
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Tabrizi, Sepehr
    Affiliation
    Obstetrics And Gynaecology Royal Women'S Hospital/Mercy
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    Document Type
    Journal Article
    Citations
    Tabrizi, S. N., Unemo, M., Golparian, D., Twin, J., Limnios, A. E., Lahra, M. & Guy, R. (2013). Analytical Evaluation of GeneXpert CT/NG, the First Genetic Point-of-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis. JOURNAL OF CLINICAL MICROBIOLOGY, 51 (6), pp.1945-1947. https://doi.org/10.1128/JCM.00806-13.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/33222
    DOI
    10.1128/JCM.00806-13
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716077
    Description

    C1 - Journal Articles Refereed
    Abstract
    GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.
    Keywords
    Infectious Diseases; Clinical Microbiology; Infectious Agents; Infectious Diseases; Reproductive System and Disorders

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