University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Centre for Neuroscience
  • Centre for Neuroscience - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Centre for Neuroscience
  • Centre for Neuroscience - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    48
    45
    Author
    Klug, M; Hill, RA; Choy, KHC; Kyrios, M; Hannan, AJ; van den Buuse, M
    Date
    2012-06-01
    Source Title
    NEUROBIOLOGY OF DISEASE
    Publisher
    ACADEMIC PRESS INC ELSEVIER SCIENCE
    University of Melbourne Author/s
    Hill, Rachel; van den Buuse, Maarten; Hannan, Anthony; Klug, Maren; Choy, Kwok Ho
    Affiliation
    Centre For Neuroscience Research
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Klug, M., Hill, R. A., Choy, K. H. C., Kyrios, M., Hannan, A. J. & van den Buuse, M. (2012). Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. NEUROBIOLOGY OF DISEASE, 46 (3), pp.722-731. https://doi.org/10.1016/j.nbd.2012.03.015.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33275
    DOI
    10.1016/j.nbd.2012.03.015
    NHMRC Grant code
    NHMRC/566879
    Description

    C1 - Journal Articles Refereed

    Abstract
    Psychiatric illnesses, such as schizophrenia, are most likely caused by an interaction between genetic predisposition and environmental factors, including stress during development. The neurotrophin, brain-derived neurotrophic factor (BDNF) has been implicated in this illness as BDNF levels are decreased in the brain of patients with schizophrenia. The aim of the present study was to assess the combined effect of reduced BDNF levels and postnatal stress, simulated by chronic young-adult treatment with the stress hormone, corticosterone. From 6 weeks of age, female and male BDNF heterozygous mice and their wild-type controls were chronically treated with corticosterone in their drinking water for 3 weeks. At 11 weeks of age, male, but not female BDNF heterozygous mice treated with corticosterone exhibited a profound memory deficit in the Y-maze. There were no differences between the groups in baseline prepulse inhibition (PPI), a measure of sensorimotor gating, or its disruption by treatment with MK-801. However, an increase in startle caused by MK-801 treatment was absent in male, but not female BDNF heterozygous mice, irrespective of corticosterone treatment. Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, NR2B and NR2C, showed a marked increase of NR2B levels in the dorsal hippocampus of male BDNF heterozygous mice treated with corticosterone. In the ventral hippocampus, significantly reduced levels of NR2A, NR2B and NR2C were observed in male BDNF heterozygous mice. The NMDA receptor effects in hippocampal sub-regions could be related to the spatial memory deficits and the loss of the effect of MK-801 on startle in these mice, respectively. No significant changes in NMDA receptor subunit levels were observed in any of the female groups. Similarly, no significant changes in levels of BDNF or its receptor, TrkB, were found other than the expected reduced levels of BDNF in heterozygous mice. In conclusion, the data show differential interactive effects of reduced levels of BDNF expression and corticosterone treatment on spatial memory and startle in male and female mice, accompanied by significant, but region-specific changes in NMDA receptor subunit levels in the dorsal and ventral hippocampus. These results could be important for our understanding of the interaction of neurodevelopmental stress and BDNF deficiency in cognitive and anxiety-related symptoms of psychiatric illnesses, such as schizophrenia.
    Keywords
    Cellular Nervous System; Central Nervous System; Nervous System and Disorders

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Centre for Neuroscience - Research Publications [86]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors