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    The Early Postnatal Nonhuman Primate Neocortex Contains Self-Renewing Multipotent Neural Progenitor Cells

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    11
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    Author
    Homman-Ludiye, J; Merson, TD; Bourne, JA
    Date
    2012-03-28
    Source Title
    PLOS ONE
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Merson, Tobias
    Affiliation
    Centre For Neuroscience Research
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Homman-Ludiye, J., Merson, T. D. & Bourne, J. A. (2012). The Early Postnatal Nonhuman Primate Neocortex Contains Self-Renewing Multipotent Neural Progenitor Cells. PLOS ONE, 7 (3), https://doi.org/10.1371/journal.pone.0034383.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/33276
    DOI
    10.1371/journal.pone.0034383
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314641
    Description

    C1 - Journal Articles Refereed

    Abstract
    The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons that take up residence within the neocortex, implying that postnatal neurogenesis could occur in this region, albeit at a low level. Evidence to support this hypothesis remains controversial while the source of putative neural progenitors responsible for generating new neurons in the postnatal neocortex is unknown. Here we report the identification of self-renewing multipotent neural progenitor cells (NPCs) derived from the postnatal day 14 (PD14) marmoset monkey primary visual cortex (V1, striate cortex). While neuronal maturation within V1 is well advanced by PD14, we observed cells throughout this region that co-expressed Sox2 and Ki67, defining a population of resident proliferating progenitor cells. When cultured at low density in the presence of epidermal growth factor (EGF) and/or fibroblast growth factor 2 (FGF-2), dissociated V1 tissue gave rise to multipotent neurospheres that exhibited the ability to differentiate into neurons, oligodendrocytes and astrocytes. While the capacity to generate neurones and oligodendrocytes was not observed beyond the third passage, astrocyte-restricted neurospheres could be maintained for up to 6 passages. This study provides the first direct evidence for the existence of multipotent NPCs within the postnatal neocortex of the nonhuman primate. The potential contribution of neocortical NPCs to neural repair following injury raises exciting new possibilities for the field of regenerative medicine.
    Keywords
    Cellular Nervous System; Nervous System and Disorders

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