Umbilical Cord Blood Testosterone and Childhood Internalizing and Externalizing Behavior: A Prospective Study
AuthorRobinson, M; Whitehouse, AJO; Jacoby, P; Mattes, E; Sawyer, MG; Keelan, JA; Hickey, M
Source TitlePLOS ONE
PublisherPUBLIC LIBRARY SCIENCE
University of Melbourne Author/sHickey, Martha
AffiliationObstetrics And Gynaecology Royal Women'S Hospital/Mercy
Document TypeJournal Article
CitationsRobinson, M., Whitehouse, A. J. O., Jacoby, P., Mattes, E., Sawyer, M. G., Keelan, J. A. & Hickey, M. (2013). Umbilical Cord Blood Testosterone and Childhood Internalizing and Externalizing Behavior: A Prospective Study. PLOS ONE, 8 (4), https://doi.org/10.1371/journal.pone.0059991.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613417
C1 - Journal Articles Refereed
Antenatal testosterone exposure influences fetal neurodevelopment and gender-role behavior in postnatal life and may contribute to differences in developmental psychopathology during childhood. We prospectively measured the associations between umbilical cord blood testosterone levels at birth and childhood behavioral development in both males and females from a large population based sample. The study comprised 430 females and 429 males from the Western Australian Pregnancy Cohort (Raine) Study where umbilical cord blood had been collected. Total testosterone concentrations were determined by mass spectrometry and bioavailable testosterone (BioT) levels were calculated. At two, five, eight and ten years of age, the participants completed the Child Behavior Checklist (CBCL). Linear regression models were used to analyse the relationship between BioT concentrations (in quartiles) and CBCL scores (total, internalizing, externalizing and selected syndrome). Boys had higher mean CBCL T-scores than girls across all ages of follow-up. There was no significant relationship between cord blood BioT quartiles and CBCL total, internalizing and externalizing T-scores at age two or five to ten combined. In the syndrome score analyses, higher BioT quartiles were associated with significantly lower scores for attention problems for boys at age five, eight and ten, and greater withdrawal symptoms in pre-school girls (age five). We did not identify a consistent relationship between antenatal testosterone exposure and total, internalizing or externalizing behavioral difficulties in childhood. Higher umbilical cord BioT levels were associated with lower scores for attention problems in boys up to 10 years and more withdrawn behavior in 5-year-old girls; however, these findings were not consistent across ages and require further investigation in a larger sample.
KeywordsObstetrics and Gynaecology; Paediatrics; Behaviour and Health; Child Health
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References