University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Patterns of chemotherapy treatment for women with invasive epithelial ovarian cancer - A population-based study

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    27
    25
    Author
    Jordan, S; Steer, C; DeFazio, A; Quinn, M; Obermair, A; Friedlander, M; Francis, J; O'Brien, S; Goss, G; Wyld, D; ...
    Date
    2013-05-01
    Source Title
    GYNECOLOGIC ONCOLOGY
    Publisher
    ACADEMIC PRESS INC ELSEVIER SCIENCE
    University of Melbourne Author/s
    QUINN, MICHAEL
    Affiliation
    Obstetrics And Gynaecology Royal Women'S Hospital/Mercy
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Jordan, S., Steer, C., DeFazio, A., Quinn, M., Obermair, A., Friedlander, M., Francis, J., O'Brien, S., Goss, G., Wyld, D. & Webb, P. (2013). Patterns of chemotherapy treatment for women with invasive epithelial ovarian cancer - A population-based study. GYNECOLOGIC ONCOLOGY, 129 (2), pp.310-317. https://doi.org/10.1016/j.ygyno.2013.02.007.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33280
    DOI
    10.1016/j.ygyno.2013.02.007
    NHMRC Grant code
    NHMRC/400281
    NHMRC/400413
    Description

    C1 - Journal Articles Refereed

    Abstract
    OBJECTIVE: Ovarian cancer five-year survival is poor at <40%. In the absence of effective screening or new treatments, ensuring all women receive optimal treatment is one avenue to improve survival. There is little population-based information regarding the primary chemotherapy treatment that women with epithelial ovarian cancer receive. This information is essential to identify potential gaps in care. METHODS: Cancer registries identified all women diagnosed with invasive epithelial ovarian cancer in Australia in 2005 (n=1192). Histopathology, chemotherapy and comorbidity information was abstracted from medical records. Multivariable logistic regression was used to identify factors associated with chemotherapy commencement, regimen, and completion. RESULTS: Women >70 years (p<0.0001), those with high-grade, stage IA/IB cancers (vs. stages IC-IV, p=0.003) and those with mucinous cancers (p=0.0002) were less likely to start chemotherapy. Most treated women received platinum-based drugs (97%), but only 68% received combination carboplatin-paclitaxel and only half completed six cycles without treatment modification/delay. Approximately 19% received single-agent carboplatin: mostly those aged >70 (p<0.0001) and/or with co-morbidities (p<0.0001). Age was the strongest predictor of completing six cycles of combination therapy. CONCLUSIONS: For specific patient groups, particularly older women, there is notable variation from standard treatment. Understanding how treatment variations affect survival and determining optimal regimens for these groups are research priorities.
    Keywords
    Chemotherapy; Obstetrics and Gynaecology; Cancer and Related Disorders; Women's Health

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52694]
    • Obstetrics and Gynaecology - Research Publications [826]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors