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    Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force

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    Author
    Frey, BN; Andreazza, AC; Houenou, J; Jamain, S; Goldstein, BI; Frye, MA; Leboyer, M; Berk, M; Malhi, GS; Lopez-Jaramillo, C; ...
    Date
    2013-04-01
    Source Title
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
    Publisher
    SAGE PUBLICATIONS LTD
    University of Melbourne Author/s
    Berk, Michael; Dodd, Seetal
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., Taylor, V. H., Dodd, S., Frangou, S., Hall, G. B., Fernandes, B. S., Kauer-Sant'Anna, M., Yatham, L. N., Kapczinski, F. & Young, L. T. (2013). Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 47 (4), pp.321-332. https://doi.org/10.1177/0004867413478217.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/33294
    DOI
    10.1177/0004867413478217
    Description

    C1 - Journal Articles Refereed

    Abstract
    Although the etiology of bipolar disorder remains uncertain, multiple studies examining neuroimaging, peripheral markers and genetics have provided important insights into the pathophysiologic processes underlying bipolar disorder. Neuroimaging studies have consistently demonstrated loss of gray matter, as well as altered activation of subcortical, anterior temporal and ventral prefrontal regions in response to emotional stimuli in bipolar disorder. Genetics studies have identified several potential candidate genes associated with increased risk for developing bipolar disorder that involve circadian rhythm, neuronal development and calcium metabolism. Notably, several groups have found decreased levels of neurotrophic factors and increased pro-inflammatory cytokines and oxidative stress markers. Together these findings provide the background for the identification of potential biomarkers for vulnerability, disease expression and to help understand the course of illness and treatment response. In other areas of medicine, validated biomarkers now inform clinical decision-making. Although the findings reviewed herein hold promise, further research involving large collaborative studies is needed to validate these potential biomarkers prior to employing them for clinical purposes. Therefore, in this positional paper from the ISBD-BIONET (biomarkers network from the International Society for Bipolar Disorders), we will discuss our view of biomarkers for these three areas: neuroimaging, peripheral measurements and genetics; and conclude the paper with our position for the next steps in the search for biomarkers for bipolar disorder.
    Keywords
    Psychiatry (incl. Psychotherapy); Neurosciences not elsewhere classified; Diagnostic Methods; Mental Health

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