Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force
AuthorFrey, BN; Andreazza, AC; Houenou, J; Jamain, S; Goldstein, BI; Frye, MA; Leboyer, M; Berk, M; Malhi, GS; Lopez-Jaramillo, C; ...
Source TitleAUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
PublisherSAGE PUBLICATIONS LTD
Document TypeJournal Article
CitationsFrey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., Taylor, V. H., Dodd, S., Frangou, S., Hall, G. B., Fernandes, B. S., Kauer-Sant'Anna, M., Yatham, L. N., Kapczinski, F. & Young, L. T. (2013). Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 47 (4), pp.321-332. https://doi.org/10.1177/0004867413478217.
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C1 - Journal Articles Refereed
Although the etiology of bipolar disorder remains uncertain, multiple studies examining neuroimaging, peripheral markers and genetics have provided important insights into the pathophysiologic processes underlying bipolar disorder. Neuroimaging studies have consistently demonstrated loss of gray matter, as well as altered activation of subcortical, anterior temporal and ventral prefrontal regions in response to emotional stimuli in bipolar disorder. Genetics studies have identified several potential candidate genes associated with increased risk for developing bipolar disorder that involve circadian rhythm, neuronal development and calcium metabolism. Notably, several groups have found decreased levels of neurotrophic factors and increased pro-inflammatory cytokines and oxidative stress markers. Together these findings provide the background for the identification of potential biomarkers for vulnerability, disease expression and to help understand the course of illness and treatment response. In other areas of medicine, validated biomarkers now inform clinical decision-making. Although the findings reviewed herein hold promise, further research involving large collaborative studies is needed to validate these potential biomarkers prior to employing them for clinical purposes. Therefore, in this positional paper from the ISBD-BIONET (biomarkers network from the International Society for Bipolar Disorders), we will discuss our view of biomarkers for these three areas: neuroimaging, peripheral measurements and genetics; and conclude the paper with our position for the next steps in the search for biomarkers for bipolar disorder.
KeywordsPsychiatry (incl. Psychotherapy); Neurosciences not elsewhere classified; Diagnostic Methods; Mental Health
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